Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital

Eyob Alemayehu Gebreyohannes, Akshaya Srikanth Bhagavathula, Tamrat Befekadu Abebe, Yonas Getaye Tefera, Tadesse Melaku Abegaz

Research output: Contribution to journalArticle

Abstract

Background: A considerable proportion of cardiovascular events could be attributed to poor adherence to antihypertensive medications. Adverse effects can be severe enough to affect adherence to antihypertensive medications. This study aimed to measure the contribution of adverse effects on antihypertensive medications adherence.

Methods: The study was conducted from May 1 to June 30, 2017, at the ambulatory clinic of University of Gondar Comprehensive Specialized Hospital (UOGCSH) in Gondar town. A binary logistic regression was performed to determine the significance of the association between adverse effects and adherence to antihypertensive medications. An institution-based cross-sectional study was conducted by administering a questionnaire to hypertensive patients who came for follow-up at the ambulatory clinic of UOGCSH. Level of adherence to antihypertensive medications was used as outcome measure.

Results: A total of 249 patients were included in the final analysis with a mean age of 56.51 years and a female majority (53%). The following variables were identified as predictors of poor adherence: tiredness [AOR (95% CI): 3.802 (1.723-8.391), p = 0.001], muscle pain [AOR (95% CI): 5.199 (1.407-19.214), p = 0.013], poor sleep [AOR (95% CI): 4.891 (1.578-15.160), p = 0.006] and, believing that the symptoms were caused by antihypertensive medications [AOR (95% CI): 3.249 (1.248-8.456), p = 0.016].

Conclusion: Adverse effect significantly contributes to antihypertensive medication non-adherence among hypertensive patients.

Original languageEnglish
Article number1
JournalClinical hypertension
Volume25
DOIs
Publication statusPublished - 2019
Externally publishedYes

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Antihypertensive Agents
Medication Adherence
Myalgia
Sleep
Cross-Sectional Studies
Logistic Models
Outcome Assessment (Health Care)

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Gebreyohannes, Eyob Alemayehu ; Bhagavathula, Akshaya Srikanth ; Abebe, Tamrat Befekadu ; Tefera, Yonas Getaye ; Abegaz, Tadesse Melaku. / Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital. In: Clinical hypertension. 2019 ; Vol. 25.
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abstract = "Background: A considerable proportion of cardiovascular events could be attributed to poor adherence to antihypertensive medications. Adverse effects can be severe enough to affect adherence to antihypertensive medications. This study aimed to measure the contribution of adverse effects on antihypertensive medications adherence.Methods: The study was conducted from May 1 to June 30, 2017, at the ambulatory clinic of University of Gondar Comprehensive Specialized Hospital (UOGCSH) in Gondar town. A binary logistic regression was performed to determine the significance of the association between adverse effects and adherence to antihypertensive medications. An institution-based cross-sectional study was conducted by administering a questionnaire to hypertensive patients who came for follow-up at the ambulatory clinic of UOGCSH. Level of adherence to antihypertensive medications was used as outcome measure.Results: A total of 249 patients were included in the final analysis with a mean age of 56.51 years and a female majority (53{\%}). The following variables were identified as predictors of poor adherence: tiredness [AOR (95{\%} CI): 3.802 (1.723-8.391), p = 0.001], muscle pain [AOR (95{\%} CI): 5.199 (1.407-19.214), p = 0.013], poor sleep [AOR (95{\%} CI): 4.891 (1.578-15.160), p = 0.006] and, believing that the symptoms were caused by antihypertensive medications [AOR (95{\%} CI): 3.249 (1.248-8.456), p = 0.016].Conclusion: Adverse effect significantly contributes to antihypertensive medication non-adherence among hypertensive patients.",
author = "Gebreyohannes, {Eyob Alemayehu} and Bhagavathula, {Akshaya Srikanth} and Abebe, {Tamrat Befekadu} and Tefera, {Yonas Getaye} and Abegaz, {Tadesse Melaku}",
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Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital. / Gebreyohannes, Eyob Alemayehu; Bhagavathula, Akshaya Srikanth; Abebe, Tamrat Befekadu; Tefera, Yonas Getaye; Abegaz, Tadesse Melaku.

In: Clinical hypertension, Vol. 25, 1, 2019.

Research output: Contribution to journalArticle

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T1 - Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital

AU - Gebreyohannes, Eyob Alemayehu

AU - Bhagavathula, Akshaya Srikanth

AU - Abebe, Tamrat Befekadu

AU - Tefera, Yonas Getaye

AU - Abegaz, Tadesse Melaku

PY - 2019

Y1 - 2019

N2 - Background: A considerable proportion of cardiovascular events could be attributed to poor adherence to antihypertensive medications. Adverse effects can be severe enough to affect adherence to antihypertensive medications. This study aimed to measure the contribution of adverse effects on antihypertensive medications adherence.Methods: The study was conducted from May 1 to June 30, 2017, at the ambulatory clinic of University of Gondar Comprehensive Specialized Hospital (UOGCSH) in Gondar town. A binary logistic regression was performed to determine the significance of the association between adverse effects and adherence to antihypertensive medications. An institution-based cross-sectional study was conducted by administering a questionnaire to hypertensive patients who came for follow-up at the ambulatory clinic of UOGCSH. Level of adherence to antihypertensive medications was used as outcome measure.Results: A total of 249 patients were included in the final analysis with a mean age of 56.51 years and a female majority (53%). The following variables were identified as predictors of poor adherence: tiredness [AOR (95% CI): 3.802 (1.723-8.391), p = 0.001], muscle pain [AOR (95% CI): 5.199 (1.407-19.214), p = 0.013], poor sleep [AOR (95% CI): 4.891 (1.578-15.160), p = 0.006] and, believing that the symptoms were caused by antihypertensive medications [AOR (95% CI): 3.249 (1.248-8.456), p = 0.016].Conclusion: Adverse effect significantly contributes to antihypertensive medication non-adherence among hypertensive patients.

AB - Background: A considerable proportion of cardiovascular events could be attributed to poor adherence to antihypertensive medications. Adverse effects can be severe enough to affect adherence to antihypertensive medications. This study aimed to measure the contribution of adverse effects on antihypertensive medications adherence.Methods: The study was conducted from May 1 to June 30, 2017, at the ambulatory clinic of University of Gondar Comprehensive Specialized Hospital (UOGCSH) in Gondar town. A binary logistic regression was performed to determine the significance of the association between adverse effects and adherence to antihypertensive medications. An institution-based cross-sectional study was conducted by administering a questionnaire to hypertensive patients who came for follow-up at the ambulatory clinic of UOGCSH. Level of adherence to antihypertensive medications was used as outcome measure.Results: A total of 249 patients were included in the final analysis with a mean age of 56.51 years and a female majority (53%). The following variables were identified as predictors of poor adherence: tiredness [AOR (95% CI): 3.802 (1.723-8.391), p = 0.001], muscle pain [AOR (95% CI): 5.199 (1.407-19.214), p = 0.013], poor sleep [AOR (95% CI): 4.891 (1.578-15.160), p = 0.006] and, believing that the symptoms were caused by antihypertensive medications [AOR (95% CI): 3.249 (1.248-8.456), p = 0.016].Conclusion: Adverse effect significantly contributes to antihypertensive medication non-adherence among hypertensive patients.

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DO - 10.1186/s40885-018-0104-6

M3 - Article

VL - 25

JO - Clinical hypertension

JF - Clinical hypertension

SN - 2056-5909

M1 - 1

ER -