Abstract
Background: A considerable proportion of cardiovascular events could be attributed to poor adherence to antihypertensive medications. Adverse effects can be severe enough to affect adherence to antihypertensive medications. This study aimed to measure the contribution of adverse effects on antihypertensive medications adherence.
Methods: The study was conducted from May 1 to June 30, 2017, at the ambulatory clinic of University of Gondar Comprehensive Specialized Hospital (UOGCSH) in Gondar town. A binary logistic regression was performed to determine the significance of the association between adverse effects and adherence to antihypertensive medications. An institution-based cross-sectional study was conducted by administering a questionnaire to hypertensive patients who came for follow-up at the ambulatory clinic of UOGCSH. Level of adherence to antihypertensive medications was used as outcome measure.
Results: A total of 249 patients were included in the final analysis with a mean age of 56.51 years and a female majority (53%). The following variables were identified as predictors of poor adherence: tiredness [AOR (95% CI): 3.802 (1.723-8.391), p = 0.001], muscle pain [AOR (95% CI): 5.199 (1.407-19.214), p = 0.013], poor sleep [AOR (95% CI): 4.891 (1.578-15.160), p = 0.006] and, believing that the symptoms were caused by antihypertensive medications [AOR (95% CI): 3.249 (1.248-8.456), p = 0.016].
Conclusion: Adverse effect significantly contributes to antihypertensive medication non-adherence among hypertensive patients.
| Original language | English |
|---|---|
| Article number | 1 |
| Journal | Clinical hypertension |
| Volume | 25 |
| DOIs | |
| Publication status | Published - 2019 |
| Externally published | Yes |
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Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital. / Gebreyohannes, Eyob Alemayehu; Bhagavathula, Akshaya Srikanth; Abebe, Tamrat Befekadu; Tefera, Yonas Getaye; Abegaz, Tadesse Melaku.
In: Clinical hypertension, Vol. 25, 1, 2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital
AU - Gebreyohannes, Eyob Alemayehu
AU - Bhagavathula, Akshaya Srikanth
AU - Abebe, Tamrat Befekadu
AU - Tefera, Yonas Getaye
AU - Abegaz, Tadesse Melaku
PY - 2019
Y1 - 2019
N2 - Background: A considerable proportion of cardiovascular events could be attributed to poor adherence to antihypertensive medications. Adverse effects can be severe enough to affect adherence to antihypertensive medications. This study aimed to measure the contribution of adverse effects on antihypertensive medications adherence.Methods: The study was conducted from May 1 to June 30, 2017, at the ambulatory clinic of University of Gondar Comprehensive Specialized Hospital (UOGCSH) in Gondar town. A binary logistic regression was performed to determine the significance of the association between adverse effects and adherence to antihypertensive medications. An institution-based cross-sectional study was conducted by administering a questionnaire to hypertensive patients who came for follow-up at the ambulatory clinic of UOGCSH. Level of adherence to antihypertensive medications was used as outcome measure.Results: A total of 249 patients were included in the final analysis with a mean age of 56.51 years and a female majority (53%). The following variables were identified as predictors of poor adherence: tiredness [AOR (95% CI): 3.802 (1.723-8.391), p = 0.001], muscle pain [AOR (95% CI): 5.199 (1.407-19.214), p = 0.013], poor sleep [AOR (95% CI): 4.891 (1.578-15.160), p = 0.006] and, believing that the symptoms were caused by antihypertensive medications [AOR (95% CI): 3.249 (1.248-8.456), p = 0.016].Conclusion: Adverse effect significantly contributes to antihypertensive medication non-adherence among hypertensive patients.
AB - Background: A considerable proportion of cardiovascular events could be attributed to poor adherence to antihypertensive medications. Adverse effects can be severe enough to affect adherence to antihypertensive medications. This study aimed to measure the contribution of adverse effects on antihypertensive medications adherence.Methods: The study was conducted from May 1 to June 30, 2017, at the ambulatory clinic of University of Gondar Comprehensive Specialized Hospital (UOGCSH) in Gondar town. A binary logistic regression was performed to determine the significance of the association between adverse effects and adherence to antihypertensive medications. An institution-based cross-sectional study was conducted by administering a questionnaire to hypertensive patients who came for follow-up at the ambulatory clinic of UOGCSH. Level of adherence to antihypertensive medications was used as outcome measure.Results: A total of 249 patients were included in the final analysis with a mean age of 56.51 years and a female majority (53%). The following variables were identified as predictors of poor adherence: tiredness [AOR (95% CI): 3.802 (1.723-8.391), p = 0.001], muscle pain [AOR (95% CI): 5.199 (1.407-19.214), p = 0.013], poor sleep [AOR (95% CI): 4.891 (1.578-15.160), p = 0.006] and, believing that the symptoms were caused by antihypertensive medications [AOR (95% CI): 3.249 (1.248-8.456), p = 0.016].Conclusion: Adverse effect significantly contributes to antihypertensive medication non-adherence among hypertensive patients.
U2 - 10.1186/s40885-018-0104-6
DO - 10.1186/s40885-018-0104-6
M3 - Article
VL - 25
JO - Clinical hypertension
JF - Clinical hypertension
SN - 2056-5909
M1 - 1
ER -