TY - JOUR
T1 - Advances in nanomaterial based optical biosensing and bioimaging of apoptosis via caspase-3 activity
T2 - a review
AU - Khalilzadeh, Balal
AU - Shadjou, Nasrin
AU - Kanberoglu, Gulsah Saydan
AU - Afsharan, Hadi
AU - de la Guardia, Miguel
AU - Charoudeh, Hojjatollah Nozad
AU - Ostadrahimi, Alireza
AU - Rashidi, Mohammad Reza
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Caspase-3 plays a vital role in intrinsic and extrinsic pathways of programed cell death and in cell proliferation. Its detection is an important tool for early detection of some cancers and apoptosis-related diseases, and for monitoring the efficacy of pharmaceuticals and of chemo- and radiotherapy of cancers. This review (with 72 references) summarizes nanomaterial based methods for signal amplification in optical methods for the determination of caspase-3 activity. Following an introduction into the field, a first large section covers optical assays, with subsections on luminescent and chemiluminescence, fluorometric (including FRET based), and colorimetric assays. Further section summarize methods for bioimaging of caspase-3. A concluding section covers current challenges and future perspectives. [Figure not available: see fulltext.].
AB - Caspase-3 plays a vital role in intrinsic and extrinsic pathways of programed cell death and in cell proliferation. Its detection is an important tool for early detection of some cancers and apoptosis-related diseases, and for monitoring the efficacy of pharmaceuticals and of chemo- and radiotherapy of cancers. This review (with 72 references) summarizes nanomaterial based methods for signal amplification in optical methods for the determination of caspase-3 activity. Following an introduction into the field, a first large section covers optical assays, with subsections on luminescent and chemiluminescence, fluorometric (including FRET based), and colorimetric assays. Further section summarize methods for bioimaging of caspase-3. A concluding section covers current challenges and future perspectives. [Figure not available: see fulltext.].
KW - Bioimaging
KW - Biomedical analysis
KW - Cancer
KW - Caspase-3
KW - Nanotechnology
KW - Optical biosensing
UR - http://www.scopus.com/inward/record.url?scp=85052662626&partnerID=8YFLogxK
U2 - 10.1007/s00604-018-2980-6
DO - 10.1007/s00604-018-2980-6
M3 - Review article
C2 - 30159750
AN - SCOPUS:85052662626
VL - 185
JO - Microchimica Acta
JF - Microchimica Acta
SN - 0026-3672
IS - 9
M1 - 434
ER -
