Advances in nanomaterial based optical biosensing and bioimaging of apoptosis via caspase-3 activity: a review

Balal Khalilzadeh, Nasrin Shadjou, Gulsah Saydan Kanberoglu, Hadi Afsharan, Miguel de la Guardia, Hojjatollah Nozad Charoudeh, Alireza Ostadrahimi, Mohammad Reza Rashidi

Research output: Contribution to journalReview articlepeer-review

52 Citations (Scopus)

Abstract

Caspase-3 plays a vital role in intrinsic and extrinsic pathways of programed cell death and in cell proliferation. Its detection is an important tool for early detection of some cancers and apoptosis-related diseases, and for monitoring the efficacy of pharmaceuticals and of chemo- and radiotherapy of cancers. This review (with 72 references) summarizes nanomaterial based methods for signal amplification in optical methods for the determination of caspase-3 activity. Following an introduction into the field, a first large section covers optical assays, with subsections on luminescent and chemiluminescence, fluorometric (including FRET based), and colorimetric assays. Further section summarize methods for bioimaging of caspase-3. A concluding section covers current challenges and future perspectives. [Figure not available: see fulltext.].

Original languageEnglish
Article number434
JournalMicrochimica Acta
Volume185
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018
Externally publishedYes

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