Advances in isolation and expansion of human cells for clinical applications

    Research output: Chapter in Book/Conference paperChapter

    Abstract

    Skin integrity is essential for normal physiological function. The capacity to regenerate is overwhelmed and integrity of the cutaneous surface is restored by scarring. The limited capacity to heal by regeneration and the sequel of scarring has driven the exploration of techniques for expedient wound treatment to restore the cutaneous barrier in a regenerative pattern.

    The development of the systems of cell isolation, proliferation, and delivery now provide a range of therapeutic options for cell-based therapies into clinical practice. The clinical outcome of the technologies is now widely reported in the literature with improved understanding of their impact on cutaneous healing. The clinical use needs to consider the patient's needs, the availability of the technology, the risk–benefit analysis, and the cost–benefit analysis.

    Tissue engineering of skin for skin repair has progressed remarkably in the recent decades with the future of healing by regeneration, a challenging but realistic goal.
    Original languageEnglish
    Title of host publicationSkin tissue Engineering and Regeneration Medicine
    EditorsMohammad Z. Albanna , James H. Holmes IV
    PublisherAcademic Press
    Pages299-315
    Number of pages17
    ISBN (Print)9780128016541
    DOIs
    Publication statusPublished - 2016

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  • Cite this

    Wood, F. (2016). Advances in isolation and expansion of human cells for clinical applications. In M. Z. Albanna , & J. H. Holmes IV (Eds.), Skin tissue Engineering and Regeneration Medicine (pp. 299-315). Academic Press. https://doi.org/10.1016/B978-0-12-801654-1.00015-2