Advances in imaging feto-placental vasculature: new tools to elucidate the early life origins of health and disease

Yutthapong Tongpob, Caitlin Wyrwoll

Research output: Contribution to journalReview articlepeer-review

5 Citations (Web of Science)

Abstract

Optimal placental function is critical for fetal development, and therefore a crucial consideration for understanding the developmental origins of health and disease (DOHaD). The structure of the fetal side of the placental vasculature is an important determinant of fetal growth and cardiovascular development. There are several imaging modalities for assessing feto-placental structure including stereology, electron microscopy, confocal microscopy, micro-computed tomography, light-sheet microscopy, ultrasonography and magnetic resonance imaging. In this review, we present current methodologies for imaging feto-placental vasculature morphology ex vivo and in vivo in human and experimental models, their advantages and limitations and how these provide insight into placental function and fetal outcomes. These imaging approaches add important perspective to our understanding of placental biology and have potential to be new tools to elucidate a deeper understanding of DOHaD.

Original languageEnglish
Pages (from-to)168-178
Number of pages11
JournalJournal of Developmental Origins of Health and Disease
Volume12
Issue number2
Early online date4 Aug 2020
DOIs
Publication statusPublished - Apr 2021

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