Advances in Biomarkers and Insulin Therapy with Relevance to Reversal of Diabetes

Ian Martins

Research output: Contribution to specialist publicationEditorialpeer-review

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Identification of biomarker tests in diabetes to assess Sirt 1 repression linked to autoimmune disease and mitophagy has become of critical importance to the expected diabetes pandemic connected to various organ diseases. Plasma Sirt 1 analysis with other biomarkers are essential to determine autoimmune disease connected to mitophagy and the reversal of Type 2/Type 3 diabetes. Insulin therapy to prevent hyperglycemia now requires Sirt 1 expression to determine mitochondrial function and insulin secretion with relevance to programmed cell death in obesity, diabetes and neurodegenerative diseases. Diet, temperature regulation and insulin therapy may improve Sirt 1 levels connected to the prevention of primary autoimmune disease in the pancreas (insulin secretion), adipose tissue, liver and brain.
Original languageEnglish
Number of pages6
Specialist publicationJournal of Studies on Diabetes
Publication statusPublished - 20 Jun 2018


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