Advances in Aging and Health Research

Ian Martins

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In the current global epidemic for chronic diseases such as non alcoholic fatty
liver disease (NAFLD), diabetes and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease have become of major concern to the developed and developing world. Appetite regulation is involved in the aging
process with the repression of anti-aging genes connected to insulin resistance
and neurodegenerative diseases. Interests in the gene-environment interactions
indicate that the anti-aging genes are connected to the metabolism of bacterial
lipopolysaccharides (LPS), drugs and xenobiotics. In the developing world relevance to gram negative bacteria and increased plasma bacterial lipopolysaccharides (LPS) outer membrane endotoxins bindto cell membranes and interfere with cholesterol and amyloid beta (Aβ) interactionswith repression of anti-aging genes to mediate accelerated neuron death. Biotherapeutics and nutritional biotherapy have become important to reverse these global chronic diseases. Biotherapeutics that involve Indian spice therapy require reassessment with relevance
Original languageEnglish
PublisherScientific Research Publishing Inc.
Number of pages172
ISBN (Electronic)9781618965707
ISBN (Print)9781618965691
Publication statusPublished - 2018


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