TY - JOUR
T1 - Advanced drug delivery strategies for diabetic retinopathy
T2 - current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities
AU - Diress, Mengistie
AU - Wagle, Susbin Raj
AU - Lim, Patrick
AU - Foster, Thomas
AU - Kovacevic, Bozica
AU - Ionescu, Corina Mihaela
AU - Mooranian, Armin
AU - Al-Salami, Hani
PY - 2024
Y1 - 2024
N2 - Introduction: Diabetic retinopathy, a significant trigger for blindness among working age individuals with diabetes, poses a substantial global health challenge. Understanding its underlying mechanisms is pivotal for developing effective treatments. Current treatment options, such as anti-VEGF agents, corticosteroids, laser photocoagulation, and vitreous surgery, have their limitations, prompting the exploration of innovative approaches like nanocapsules based drug-delivery systems. Nanoparticles provide promising solutions to improve drug delivery in ocular medicine, overcoming the complexities of ocular anatomy and existing treatment constraints. Areas covered: This review explored advanced therapeutic strategies for diabetic retinopathy, focusing on current medications with their limitations, drug delivery methods, device innovations, and overcoming associated barriers. Through comprehensive review, it aimed to contribute to the discovery of more efficient management strategies for diabetic retinopathy in the future. Expert opinion: In the next five to ten years, we expect a revolutionary shift in how diabetic retinopathy is treated. As we deepen our understanding of oxidative stress and metabolic dysfunction, antioxidants with specialised delivery matrices are poised to take center stage in prevention and treatment strategies. Our vision is to create a more integrated approach to diabetic retinopathy management that not only improves patient outcomes but also reduces the risks associated to traditional therapies.
AB - Introduction: Diabetic retinopathy, a significant trigger for blindness among working age individuals with diabetes, poses a substantial global health challenge. Understanding its underlying mechanisms is pivotal for developing effective treatments. Current treatment options, such as anti-VEGF agents, corticosteroids, laser photocoagulation, and vitreous surgery, have their limitations, prompting the exploration of innovative approaches like nanocapsules based drug-delivery systems. Nanoparticles provide promising solutions to improve drug delivery in ocular medicine, overcoming the complexities of ocular anatomy and existing treatment constraints. Areas covered: This review explored advanced therapeutic strategies for diabetic retinopathy, focusing on current medications with their limitations, drug delivery methods, device innovations, and overcoming associated barriers. Through comprehensive review, it aimed to contribute to the discovery of more efficient management strategies for diabetic retinopathy in the future. Expert opinion: In the next five to ten years, we expect a revolutionary shift in how diabetic retinopathy is treated. As we deepen our understanding of oxidative stress and metabolic dysfunction, antioxidants with specialised delivery matrices are poised to take center stage in prevention and treatment strategies. Our vision is to create a more integrated approach to diabetic retinopathy management that not only improves patient outcomes but also reduces the risks associated to traditional therapies.
KW - bile acids
KW - diabetic retinopathy
KW - Drug delivery
KW - nanoparticles
KW - polymers
KW - probucol
UR - http://www.scopus.com/inward/record.url?scp=85211489190&partnerID=8YFLogxK
U2 - 10.1080/17425247.2024.2431577
DO - 10.1080/17425247.2024.2431577
M3 - Review article
C2 - 39557623
AN - SCOPUS:85211489190
SN - 1742-5247
VL - 21
SP - 1859
EP - 1877
JO - Expert Opinion on Drug Delivery
JF - Expert Opinion on Drug Delivery
IS - 12
ER -