Advanced Biomaterials for Tendon and Ligament Regeneration

Behzad Shiroud Heidari

doi:10.26182/k0s8-zd64

Advanced Biomaterials for Tendon and Ligament Regeneration

Behzad Shiroud Heidari

School of Engineering

Research output: Thesis › Doctoral Thesis

54 Downloads (Pure)

Abstract

Tendon and ligament (TL) injuries affect millions of people annually. Biopolymers play a significant role in TL tissue repair. Many biopolymers have been studied for TL regeneration; however, finding the right balance in mechanical properties and degradation rates remains a challenge, not only at the time of implantation but also during the biodegradation process. There is a need for improved biopolymers suitable for TL scaffolds. This thesis seeks to develop novel synthetic and natural biopolymers for TL regeneration applications, such as anterior cruciate ligaments, complex tendon/ligament-bone junction, and augmentation of repaired tendons.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Juan Pardo, Elena, Supervisor Doyle, Barry, Supervisor Zheng, Minghao, Supervisor
Award date	14 Mar 2023
DOIs	https://doi.org/10.26182/k0s8-zd64
Publication status	Unpublished - 2022

Embargo information

Embargoed from 16/03/2023 to 29/12/2024. Made publicly available on 29/12/2024.

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10.26182/k0s8-zd64

THESIS - DOCTOR OF PHILOSOPHY - SHIROUD HEIDARI, Behzard - 2022
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3 Article
2 Review article
1 Abstract
1 Patent

Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments
Heidari, B. S., Ruan, R., Vahabli, E., Chen, P., De-Juan-Pardo, E. M., Zheng, M. & Doyle, B., Jan 2023, In: Bioactive Materials. 19, p. 179-197 19 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
65 Citations (Scopus)
Novel hybrid biocomposites for tendon grafts: The addition of silk to polydioxanone and poly(lactide-co-caprolactone) enhances material properties, in vitro and in vivo biocompatibility
Shiroud Heidari, B., Muiños Lopez, E., Harrington, E., Ruan, R., Chen, P., Davachi, S. M., Allardyce, B., Rajkhowa, R., Dilley, R., Granero-Moltó, F., De-Juan-Pardo, E. M., Zheng, M. & Doyle, B., Jul 2023, In: Bioactive Materials. 25, p. 291-306 16 p.
Research output: Contribution to journal › Article › peer-review

Open Access
18 Citations (Scopus)
Silane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responses
Shiroud Heidari, B., Lopez, E. M., Chen, P., Ruan, R., Vahabli, E., Davachi, S. M., Granero-Moltó, F., De-Juan-Pardo, E. M., Zheng, M. & Doyle, B., Oct 2023, In: Materials Today Bio. 22, 17 p., 100778.
Research output: Contribution to journal › Article › peer-review

Open Access
17 Citations (Web of Science)

Cite this

@phdthesis{f0a9b224d93f4dcbb9fd605facb28624,

title = "Advanced Biomaterials for Tendon and Ligament Regeneration",

abstract = "Tendon and ligament (TL) injuries affect millions of people annually. Biopolymers play a significant role in TL tissue repair. Many biopolymers have been studied for TL regeneration; however, finding the right balance in mechanical properties and degradation rates remains a challenge, not only at the time of implantation but also during the biodegradation process. There is a need for improved biopolymers suitable for TL scaffolds. This thesis seeks to develop novel synthetic and natural biopolymers for TL regeneration applications, such as anterior cruciate ligaments, complex tendon/ligament-bone junction, and augmentation of repaired tendons.",

keywords = "Biopolymers, Tendon and ligament regeneration, Tendon-bone interface tissues, Polydioxanone, Poly(lactide-co-caprolactone), Collagen membrane, Hydrogels",

author = "{Shiroud Heidari}, Behzad",

year = "2022",

doi = "10.26182/k0s8-zd64",

language = "English",

school = "The University of Western Australia",

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AU - Shiroud Heidari, Behzad

PY - 2022

Y1 - 2022

N2 - Tendon and ligament (TL) injuries affect millions of people annually. Biopolymers play a significant role in TL tissue repair. Many biopolymers have been studied for TL regeneration; however, finding the right balance in mechanical properties and degradation rates remains a challenge, not only at the time of implantation but also during the biodegradation process. There is a need for improved biopolymers suitable for TL scaffolds. This thesis seeks to develop novel synthetic and natural biopolymers for TL regeneration applications, such as anterior cruciate ligaments, complex tendon/ligament-bone junction, and augmentation of repaired tendons.

AB - Tendon and ligament (TL) injuries affect millions of people annually. Biopolymers play a significant role in TL tissue repair. Many biopolymers have been studied for TL regeneration; however, finding the right balance in mechanical properties and degradation rates remains a challenge, not only at the time of implantation but also during the biodegradation process. There is a need for improved biopolymers suitable for TL scaffolds. This thesis seeks to develop novel synthetic and natural biopolymers for TL regeneration applications, such as anterior cruciate ligaments, complex tendon/ligament-bone junction, and augmentation of repaired tendons.

KW - Biopolymers

KW - Tendon and ligament regeneration

KW - Tendon-bone interface tissues

KW - Polydioxanone

KW - Poly(lactide-co-caprolactone)

KW - Collagen membrane

KW - Hydrogels

U2 - 10.26182/k0s8-zd64

DO - 10.26182/k0s8-zd64

M3 - Doctoral Thesis

ER -

Advanced Biomaterials for Tendon and Ligament Regeneration

Abstract

Embargo information

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Research output

Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments

Novel hybrid biocomposites for tendon grafts: The addition of silk to polydioxanone and poly(lactide-co-caprolactone) enhances material properties, in vitro and in vivo biocompatibility

Silane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responses

Cite this