Adult onset Still's disease

Research output: Chapter in Book/Conference paperChapter

Abstract

Adult-onset Still’s disease is an uncommon autoimmune
inflammatory disease, most often seen in young adults.
 it presents as a combination of systemic manifestations typically
including spiking fevers, short-lived rashes, and joint symptoms
ranging from arthralgia to aggressive arthritis.
 no specifc diagnostic test is available; the clinical diagnosis is
based on pattern recognition and exclusion.
 the disease remits in a third of patients, whereas a debilitating
disease course is mainly seen in those with root joint involvement.
 modern treatment options include monoclonal antibodies that
inhibit cytokine effects; however, there is a striking lack of clinical
trials.
Original languageEnglish
Title of host publicationRheumatology
EditorsMarc Hochberg, Alan Silman, Joseph Smolen
Place of PublicationPhiladelphia
PublisherElsevier - Mosby
Chapter84
Number of pages10
Edition5th
ISBN (Print)9780323065511
Publication statusPublished - 29 Oct 2011

Fingerprint

Adult-Onset Still's Disease
Joints
Arthralgia
Exanthema
Routine Diagnostic Tests
Arthritis
Young Adult
Fever
Monoclonal Antibodies
Cytokines
Therapeutics

Cite this

Nossent, J. C. (2011). Adult onset Still's disease. In M. Hochberg, A. Silman, & J. Smolen (Eds.), Rheumatology (5th ed.). Philadelphia: Elsevier - Mosby.
Nossent, Johannes Cornelis. / Adult onset Still's disease. Rheumatology. editor / Marc Hochberg ; Alan Silman ; Joseph Smolen. 5th . ed. Philadelphia : Elsevier - Mosby, 2011.
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Nossent, JC 2011, Adult onset Still's disease. in M Hochberg, A Silman & J Smolen (eds), Rheumatology. 5th edn, Elsevier - Mosby, Philadelphia.

Adult onset Still's disease. / Nossent, Johannes Cornelis.

Rheumatology. ed. / Marc Hochberg; Alan Silman; Joseph Smolen. 5th . ed. Philadelphia : Elsevier - Mosby, 2011.

Research output: Chapter in Book/Conference paperChapter

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AU - Nossent, Johannes Cornelis

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Y1 - 2011/10/29

N2 - Adult-onset Still’s disease is an uncommon autoimmuneinflammatory disease, most often seen in young adults. it presents as a combination of systemic manifestations typicallyincluding spiking fevers, short-lived rashes, and joint symptomsranging from arthralgia to aggressive arthritis. no specifc diagnostic test is available; the clinical diagnosis isbased on pattern recognition and exclusion. the disease remits in a third of patients, whereas a debilitatingdisease course is mainly seen in those with root joint involvement. modern treatment options include monoclonal antibodies thatinhibit cytokine effects; however, there is a striking lack of clinicaltrials.

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M3 - Chapter

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BT - Rheumatology

A2 - Hochberg, Marc

A2 - Silman, Alan

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PB - Elsevier - Mosby

CY - Philadelphia

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Nossent JC. Adult onset Still's disease. In Hochberg M, Silman A, Smolen J, editors, Rheumatology. 5th ed. Philadelphia: Elsevier - Mosby. 2011