Adult onset Still's disease

Adult-onset Still’s disease is an uncommon autoimmune
inflammatory disease, most often seen in young adults.
 it presents as a combination of systemic manifestations typically
including spiking fevers, short-lived rashes, and joint symptoms
ranging from arthralgia to aggressive arthritis.
 no specifc diagnostic test is available; the clinical diagnosis is
based on pattern recognition and exclusion.
 the disease remits in a third of patients, whereas a debilitating
disease course is mainly seen in those with root joint involvement.
 modern treatment options include monoclonal antibodies that
inhibit cytokine effects; however, there is a striking lack of clinical
trials.