Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008)

K. Sim, K.A.H. Yong, Y.H. Chan, P.C. Tor, Y.T. Xiang, C.Y. Wang, E.H.M. Lee, S. Fujii, S.Y. Yang, M.Y. Chong, Gabor Ungvari, T.M. Si, Y.L. He, E.K. Chung, K.Y. Chee, J. Trivedi, P. Udomratn, N. Shinfuku, E.H. Kua, C.H. Tan & 2 others N. Sartorius, R.J. Baldessarini

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    Abstract

    Recent studies indicate relatively high international rates of adjunctive psychotropic medication, including mood stabilizers, for patients with schizophrenia. Since such treatments are little studied in Asia, we examined the frequency of mood-stabilizer use and its clinical correlates among hospitalized Asian patients diagnosed with schizophrenia in 2001-2008. We evaluated usage rates of mood stabilizers with antipsychotic drugs, and associated factors, for in-patients diagnosed with DSM-IV schizophrenia in 2001, 2004 and 2008 in nine Asian regions : China, Hong Kong, India, Korea, Japan, Malaysia, Taiwan, Thailand, and Singapore. Overall, mood stabilizers were given to 20.4% (n =1377/6761) of hospitalized schizophrenia patients, with increased usage over time. Mood-stabilizer use was significantly and independently associated in multivariate logistic modeling with : aggressive behaviour, disorganized speech, year sampled (2008 vs. earlier), multiple hospitalizations, less negative symptoms, younger age, with regional variation (Japan, Hong Kong, Singapore > Taiwan or China). Co-prescription of adjunctive mood stabilizers with antipsychotics for hospitalized Asian schizophrenia patients increased over the past decade, and was associated with specific clinical characteristics. This practice parallels findings in other countries and illustrates ongoing tension between evidence-based practice vs. individualized, empirical treatment of psychotic disorders.
    Original languageEnglish
    Pages (from-to)1157-1164
    JournalInternational Journal of Neuropsychopharmacology
    Volume14
    DOIs
    Publication statusPublished - 2011

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    Prescriptions
    Schizophrenia
    Singapore
    Hong Kong
    Taiwan
    Antipsychotic Agents
    China
    Japan
    Therapeutics
    Evidence-Based Practice
    Malaysia
    Thailand
    Korea
    Diagnostic and Statistical Manual of Mental Disorders
    Psychotic Disorders
    India
    Hospitalization

    Cite this

    Sim, K. ; Yong, K.A.H. ; Chan, Y.H. ; Tor, P.C. ; Xiang, Y.T. ; Wang, C.Y. ; Lee, E.H.M. ; Fujii, S. ; Yang, S.Y. ; Chong, M.Y. ; Ungvari, Gabor ; Si, T.M. ; He, Y.L. ; Chung, E.K. ; Chee, K.Y. ; Trivedi, J. ; Udomratn, P. ; Shinfuku, N. ; Kua, E.H. ; Tan, C.H. ; Sartorius, N. ; Baldessarini, R.J. / Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008). In: International Journal of Neuropsychopharmacology. 2011 ; Vol. 14. pp. 1157-1164.
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    abstract = "Recent studies indicate relatively high international rates of adjunctive psychotropic medication, including mood stabilizers, for patients with schizophrenia. Since such treatments are little studied in Asia, we examined the frequency of mood-stabilizer use and its clinical correlates among hospitalized Asian patients diagnosed with schizophrenia in 2001-2008. We evaluated usage rates of mood stabilizers with antipsychotic drugs, and associated factors, for in-patients diagnosed with DSM-IV schizophrenia in 2001, 2004 and 2008 in nine Asian regions : China, Hong Kong, India, Korea, Japan, Malaysia, Taiwan, Thailand, and Singapore. Overall, mood stabilizers were given to 20.4{\%} (n =1377/6761) of hospitalized schizophrenia patients, with increased usage over time. Mood-stabilizer use was significantly and independently associated in multivariate logistic modeling with : aggressive behaviour, disorganized speech, year sampled (2008 vs. earlier), multiple hospitalizations, less negative symptoms, younger age, with regional variation (Japan, Hong Kong, Singapore > Taiwan or China). Co-prescription of adjunctive mood stabilizers with antipsychotics for hospitalized Asian schizophrenia patients increased over the past decade, and was associated with specific clinical characteristics. This practice parallels findings in other countries and illustrates ongoing tension between evidence-based practice vs. individualized, empirical treatment of psychotic disorders.",
    author = "K. Sim and K.A.H. Yong and Y.H. Chan and P.C. Tor and Y.T. Xiang and C.Y. Wang and E.H.M. Lee and S. Fujii and S.Y. Yang and M.Y. Chong and Gabor Ungvari and T.M. Si and Y.L. He and E.K. Chung and K.Y. Chee and J. Trivedi and P. Udomratn and N. Shinfuku and E.H. Kua and C.H. Tan and N. Sartorius and R.J. Baldessarini",
    year = "2011",
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    language = "English",
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    pages = "1157--1164",
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    Sim, K, Yong, KAH, Chan, YH, Tor, PC, Xiang, YT, Wang, CY, Lee, EHM, Fujii, S, Yang, SY, Chong, MY, Ungvari, G, Si, TM, He, YL, Chung, EK, Chee, KY, Trivedi, J, Udomratn, P, Shinfuku, N, Kua, EH, Tan, CH, Sartorius, N & Baldessarini, RJ 2011, 'Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008)' International Journal of Neuropsychopharmacology, vol. 14, pp. 1157-1164. https://doi.org/10.1017/S1461145711000563

    Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008). / Sim, K.; Yong, K.A.H.; Chan, Y.H.; Tor, P.C.; Xiang, Y.T.; Wang, C.Y.; Lee, E.H.M.; Fujii, S.; Yang, S.Y.; Chong, M.Y.; Ungvari, Gabor; Si, T.M.; He, Y.L.; Chung, E.K.; Chee, K.Y.; Trivedi, J.; Udomratn, P.; Shinfuku, N.; Kua, E.H.; Tan, C.H.; Sartorius, N.; Baldessarini, R.J.

    In: International Journal of Neuropsychopharmacology, Vol. 14, 2011, p. 1157-1164.

    Research output: Contribution to journalArticle

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    AU - Sim, K.

    AU - Yong, K.A.H.

    AU - Chan, Y.H.

    AU - Tor, P.C.

    AU - Xiang, Y.T.

    AU - Wang, C.Y.

    AU - Lee, E.H.M.

    AU - Fujii, S.

    AU - Yang, S.Y.

    AU - Chong, M.Y.

    AU - Ungvari, Gabor

    AU - Si, T.M.

    AU - He, Y.L.

    AU - Chung, E.K.

    AU - Chee, K.Y.

    AU - Trivedi, J.

    AU - Udomratn, P.

    AU - Shinfuku, N.

    AU - Kua, E.H.

    AU - Tan, C.H.

    AU - Sartorius, N.

    AU - Baldessarini, R.J.

    PY - 2011

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    AB - Recent studies indicate relatively high international rates of adjunctive psychotropic medication, including mood stabilizers, for patients with schizophrenia. Since such treatments are little studied in Asia, we examined the frequency of mood-stabilizer use and its clinical correlates among hospitalized Asian patients diagnosed with schizophrenia in 2001-2008. We evaluated usage rates of mood stabilizers with antipsychotic drugs, and associated factors, for in-patients diagnosed with DSM-IV schizophrenia in 2001, 2004 and 2008 in nine Asian regions : China, Hong Kong, India, Korea, Japan, Malaysia, Taiwan, Thailand, and Singapore. Overall, mood stabilizers were given to 20.4% (n =1377/6761) of hospitalized schizophrenia patients, with increased usage over time. Mood-stabilizer use was significantly and independently associated in multivariate logistic modeling with : aggressive behaviour, disorganized speech, year sampled (2008 vs. earlier), multiple hospitalizations, less negative symptoms, younger age, with regional variation (Japan, Hong Kong, Singapore > Taiwan or China). Co-prescription of adjunctive mood stabilizers with antipsychotics for hospitalized Asian schizophrenia patients increased over the past decade, and was associated with specific clinical characteristics. This practice parallels findings in other countries and illustrates ongoing tension between evidence-based practice vs. individualized, empirical treatment of psychotic disorders.

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