Adjudicating paravalvular leaks of transcatheter aortic valves: a critical appraisal

Mohammad Abdelghani, Osama I I Soliman, Carl Schultz, Alec Vahanian, Patrick W Serruys

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Paravalvular leakage (PVL) is an important complication of transcatheter aortic valve implantation (TAVI). It contributed to the erosion of the clinical benefits of TAVI and confidence of its adoption as a default therapy in low surgical-risk patients. Newer TAVI technologies are provided with effective paravalvular sealing as well as retrieval/reposition mechanisms that are believed to considerably lower the risk of PVL. Meanwhile, developments in timely detection and accurate quantitation of PVL remain lagging behind those technological advances. The Valve Academic Research Consortium-standardized criteria of PVL assessment are based on echocardiography and are, according to experts' opinion, not adequately validated. Peri-procedural diagnosis, based on angiographic, haemodynamic, and/or echocardiographic methods, is so far without standardization of acquisition or interpretation. The aim of this report is to review the strengths and limitations of the current technologies used for PVL adjudication. Understanding this strengths/limitations ratio is important to define an appropriate scheme for detection and quantitation of PVLs both in clinical trials and in routine clinical practice.

Original languageEnglish
Pages (from-to)2627-2644
Number of pages18
JournalEuropean Heart Journal
Issue number34
Publication statusPublished - 7 Sep 2016


Dive into the research topics of 'Adjudicating paravalvular leaks of transcatheter aortic valves: a critical appraisal'. Together they form a unique fingerprint.

Cite this