Additivity of threshold elevations produced by disruption of outer hair cell function

Robert Patuzzi, R. Rajan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We present a simple model describing the additivity of hearing loss in the mammalian cochlea produced by disruption of the outer hair cell transduction processes. The validity of this model has been tested experimentally in the guinea-pig by inducing threshold elevations using two simultaneous cochlear manipulations, including acoustic overstimulation, two-tone suppression, low-frequency acoustic biasing of the cochlear partition and electrical stimulation of the medial olivo-cochlear system of efferent fibres. The results of these experiments suggest that the model presented is an adequate description, within the measurement error of our experiments, of the hearing losses produced.
Original languageEnglish
Pages (from-to)165-177
JournalHearing Research
Volume60
DOIs
Publication statusPublished - 1992

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Outer Auditory Hair Cells
Cochlea
Hearing Loss
Acoustics
Electric Stimulation
Guinea Pigs

Cite this

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abstract = "We present a simple model describing the additivity of hearing loss in the mammalian cochlea produced by disruption of the outer hair cell transduction processes. The validity of this model has been tested experimentally in the guinea-pig by inducing threshold elevations using two simultaneous cochlear manipulations, including acoustic overstimulation, two-tone suppression, low-frequency acoustic biasing of the cochlear partition and electrical stimulation of the medial olivo-cochlear system of efferent fibres. The results of these experiments suggest that the model presented is an adequate description, within the measurement error of our experiments, of the hearing losses produced.",
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Additivity of threshold elevations produced by disruption of outer hair cell function. / Patuzzi, Robert; Rajan, R.

In: Hearing Research, Vol. 60, 1992, p. 165-177.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Additivity of threshold elevations produced by disruption of outer hair cell function

AU - Patuzzi, Robert

AU - Rajan, R.

PY - 1992

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N2 - We present a simple model describing the additivity of hearing loss in the mammalian cochlea produced by disruption of the outer hair cell transduction processes. The validity of this model has been tested experimentally in the guinea-pig by inducing threshold elevations using two simultaneous cochlear manipulations, including acoustic overstimulation, two-tone suppression, low-frequency acoustic biasing of the cochlear partition and electrical stimulation of the medial olivo-cochlear system of efferent fibres. The results of these experiments suggest that the model presented is an adequate description, within the measurement error of our experiments, of the hearing losses produced.

AB - We present a simple model describing the additivity of hearing loss in the mammalian cochlea produced by disruption of the outer hair cell transduction processes. The validity of this model has been tested experimentally in the guinea-pig by inducing threshold elevations using two simultaneous cochlear manipulations, including acoustic overstimulation, two-tone suppression, low-frequency acoustic biasing of the cochlear partition and electrical stimulation of the medial olivo-cochlear system of efferent fibres. The results of these experiments suggest that the model presented is an adequate description, within the measurement error of our experiments, of the hearing losses produced.

U2 - 10.1016/0378-5955(92)90019-J

DO - 10.1016/0378-5955(92)90019-J

M3 - Article

VL - 60

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EP - 177

JO - Hearing Research

JF - Hearing Research

SN - 0378-5955

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