Addition of MT, D16S10, D16S4, and D16S91 to the linkage map within 16q12.1-q22.1

H. M. Kozman; A. K. Gedeon; S. Whitmore; G. K. Suthers; D. F. Callen; G. R. Sutherland; J. C. Mulley

doi:10.1016/0888-7543(91)90085-S

Addition of MT, D16S10, D16S4, and D16S91 to the linkage map within 16q12.1-q22.1

H. M. Kozman, A. K. Gedeon, S. Whitmore, G. K. Suthers, D. F. Callen, G. R. Sutherland, J. C. Mulley

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

A 10-point genetic linkage map of the region 16q12.1 to 16q22.1 has been constructed using the CEPH reference families. Four loci, MT, D16S10, D16S91, and D16S4, not previously localized on a multipoint linkage map, were incorporated on the map presented here. The order of loci was cen-D16S39-MT, D16S65-D16S10-FRA16B-D16S38, D16S4, D16S91, D16S46-D16S47-HP-qter. The interval between D16S10 and 4D16S38 is 3.1 cM in males and 2.3 cM in females, and contains FRA16B. The cloning strategy for FRA16B will now be based on YAC walking from D16S10 and D16S38. The location of FRA16B between D16S10 and D16S38 provides a physical reference point for the multipoint linkage map on the short arm of chromosome 16.

Original language	English
Pages (from-to)	756-759
Number of pages	4
Journal	Genomics
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(91)90085-S
Publication status	Published - 1 Jan 1991
Externally published	Yes

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@article{664b35fc118c492a92ca7ba905b051c2,

title = "Addition of MT, D16S10, D16S4, and D16S91 to the linkage map within 16q12.1-q22.1",

abstract = "A 10-point genetic linkage map of the region 16q12.1 to 16q22.1 has been constructed using the CEPH reference families. Four loci, MT, D16S10, D16S91, and D16S4, not previously localized on a multipoint linkage map, were incorporated on the map presented here. The order of loci was cen-D16S39-MT, D16S65-D16S10-FRA16B-D16S38, D16S4, D16S91, D16S46-D16S47-HP-qter. The interval between D16S10 and 4D16S38 is 3.1 cM in males and 2.3 cM in females, and contains FRA16B. The cloning strategy for FRA16B will now be based on YAC walking from D16S10 and D16S38. The location of FRA16B between D16S10 and D16S38 provides a physical reference point for the multipoint linkage map on the short arm of chromosome 16.",

author = "Kozman, {H. M.} and Gedeon, {A. K.} and S. Whitmore and Suthers, {G. K.} and Callen, {D. F.} and Sutherland, {G. R.} and Mulley, {J. C.}",

year = "1991",

month = jan,

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doi = "10.1016/0888-7543(91)90085-S",

language = "English",

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T1 - Addition of MT, D16S10, D16S4, and D16S91 to the linkage map within 16q12.1-q22.1

AU - Kozman, H. M.

AU - Gedeon, A. K.

AU - Whitmore, S.

AU - Suthers, G. K.

AU - Callen, D. F.

AU - Sutherland, G. R.

AU - Mulley, J. C.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - A 10-point genetic linkage map of the region 16q12.1 to 16q22.1 has been constructed using the CEPH reference families. Four loci, MT, D16S10, D16S91, and D16S4, not previously localized on a multipoint linkage map, were incorporated on the map presented here. The order of loci was cen-D16S39-MT, D16S65-D16S10-FRA16B-D16S38, D16S4, D16S91, D16S46-D16S47-HP-qter. The interval between D16S10 and 4D16S38 is 3.1 cM in males and 2.3 cM in females, and contains FRA16B. The cloning strategy for FRA16B will now be based on YAC walking from D16S10 and D16S38. The location of FRA16B between D16S10 and D16S38 provides a physical reference point for the multipoint linkage map on the short arm of chromosome 16.

AB - A 10-point genetic linkage map of the region 16q12.1 to 16q22.1 has been constructed using the CEPH reference families. Four loci, MT, D16S10, D16S91, and D16S4, not previously localized on a multipoint linkage map, were incorporated on the map presented here. The order of loci was cen-D16S39-MT, D16S65-D16S10-FRA16B-D16S38, D16S4, D16S91, D16S46-D16S47-HP-qter. The interval between D16S10 and 4D16S38 is 3.1 cM in males and 2.3 cM in females, and contains FRA16B. The cloning strategy for FRA16B will now be based on YAC walking from D16S10 and D16S38. The location of FRA16B between D16S10 and D16S38 provides a physical reference point for the multipoint linkage map on the short arm of chromosome 16.

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