Abstract
A 10-point genetic linkage map of the region 16q12.1 to 16q22.1 has been constructed using the CEPH reference families. Four loci, MT, D16S10, D16S91, and D16S4, not previously localized on a multipoint linkage map, were incorporated on the map presented here. The order of loci was cen-D16S39-MT, D16S65-D16S10-FRA16B-D16S38, D16S4, D16S91, D16S46-D16S47-HP-qter. The interval between D16S10 and 4D16S38 is 3.1 cM in males and 2.3 cM in females, and contains FRA16B. The cloning strategy for FRA16B will now be based on YAC walking from D16S10 and D16S38. The location of FRA16B between D16S10 and D16S38 provides a physical reference point for the multipoint linkage map on the short arm of chromosome 16.
| Original language | English |
|---|---|
| Pages (from-to) | 756-759 |
| Number of pages | 4 |
| Journal | Genomics |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Jan 1991 |
| Externally published | Yes |
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Addition of MT, D16S10, D16S4, and D16S91 to the linkage map within 16q12.1-q22.1. / Kozman, H. M.; Gedeon, A. K.; Whitmore, S.; Suthers, G. K.; Callen, D. F.; Sutherland, G. R.; Mulley, J. C.
In: Genomics, Vol. 11, No. 3, 01.01.1991, p. 756-759.Research output: Contribution to journal › Article
TY - JOUR
T1 - Addition of MT, D16S10, D16S4, and D16S91 to the linkage map within 16q12.1-q22.1
AU - Kozman, H. M.
AU - Gedeon, A. K.
AU - Whitmore, S.
AU - Suthers, G. K.
AU - Callen, D. F.
AU - Sutherland, G. R.
AU - Mulley, J. C.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - A 10-point genetic linkage map of the region 16q12.1 to 16q22.1 has been constructed using the CEPH reference families. Four loci, MT, D16S10, D16S91, and D16S4, not previously localized on a multipoint linkage map, were incorporated on the map presented here. The order of loci was cen-D16S39-MT, D16S65-D16S10-FRA16B-D16S38, D16S4, D16S91, D16S46-D16S47-HP-qter. The interval between D16S10 and 4D16S38 is 3.1 cM in males and 2.3 cM in females, and contains FRA16B. The cloning strategy for FRA16B will now be based on YAC walking from D16S10 and D16S38. The location of FRA16B between D16S10 and D16S38 provides a physical reference point for the multipoint linkage map on the short arm of chromosome 16.
AB - A 10-point genetic linkage map of the region 16q12.1 to 16q22.1 has been constructed using the CEPH reference families. Four loci, MT, D16S10, D16S91, and D16S4, not previously localized on a multipoint linkage map, were incorporated on the map presented here. The order of loci was cen-D16S39-MT, D16S65-D16S10-FRA16B-D16S38, D16S4, D16S91, D16S46-D16S47-HP-qter. The interval between D16S10 and 4D16S38 is 3.1 cM in males and 2.3 cM in females, and contains FRA16B. The cloning strategy for FRA16B will now be based on YAC walking from D16S10 and D16S38. The location of FRA16B between D16S10 and D16S38 provides a physical reference point for the multipoint linkage map on the short arm of chromosome 16.
UR - http://www.scopus.com/inward/record.url?scp=0026095263&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(91)90085-S
DO - 10.1016/0888-7543(91)90085-S
M3 - Article
VL - 11
SP - 756
EP - 759
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 3
ER -