Adaptive optics-assisted optical coherence tomography for imaging of patients with age related macular degeneration

Kenta Sudo, Barry Cense

Research output: Chapter in Book/Conference paperConference paper

3 Citations (Scopus)


We developed an optical coherence tomography (OCT) prototype with a sample arm that uses a 3.4 mm beam, which is considerably larger than the 1.2 to 1.5 mm beam that is used in commercialized OCT systems. The system is equipped with adaptive optics (AO), and to distinguish it from traditional AO-OCT systems with a larger 6 mm beam we have coined this concept AO-assisted OCT. Compared to commercialized OCT systems, the 3.4 mm aperture combined with AO improves light collection efficiency and imaging lateral resolution. In this paper, the performance of the AOa-OCT system was compared to a standard OCT system and demonstrated for imaging of age-related macular degeneration (AMD). Measurements were performed on the retinas of three human volunteers with healthy eyes and on one eye of a patient diagnosed with AMD. The AO-assisted OCT system imaged retinal structures of healthy human eyes and a patient eye affected by AMD with higher lateral resolution and a 9 degrees by 9 degrees field of view. This combination of a large isoplanatic patch and high lateral resolution can be expected to fill a gap between standard OCT with a 1.2 mm beam and conventional AO-OCT with a 6 mm beam and a 1.5 degrees by 1.5 degrees isoplanatic patch.

Original languageEnglish
Title of host publicationProceedings of SPIE 8567, Ophthalmic Technologies XXIII, 85671W (2013)
EditorsF Manns, PG Soderberg, A Ho
Number of pages7
Publication statusPublished - 2013
Externally publishedYes
EventConference on Ophthalmic Technologies XXIII as a part of the SPIE Photonics West BiOS Meeting - The Moscone Cente, San Francisco, United States
Duration: 2 Feb 20133 Feb 2013
Conference number: 8567

Publication series

NameProceedings of SPIE
ISSN (Print)0277-786X


ConferenceConference on Ophthalmic Technologies XXIII as a part of the SPIE Photonics West BiOS Meeting
Abbreviated titleOphthalmic Technologies XXIII
CountryUnited States
CitySan Francisco

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