© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. • This guideline summary describes the fourth edition of Acute pain management: scientific evidence, which was published by the Australian and New Zealand College of Anaesthetists (ANZCA) and its Faculty of Pain Medicine (FPMANZCA) in December 2015. • The fourth edition summarises the best available evidence on acute pain management, following methods established over the preceding three editions. • It provides additional information by scoring the quality of and reporting further details on randomised controlled trials and meta-analyses. • The information is condensed into key messages that provide: ? concise statements on each topic, showing the highest level of evidence; and ? clinical practice points based on clinical experience or expert opinion.