Acute myeloid leukaemia relapsing after allogeneic haemopoietic stem cell transplantation: prognostic factors and impact of initial therapy of relapse

Andrew B. M. Lim, Cameron Curley, Chun Y. Fong, Ian Bilmon, Ashanka Beligaswatte, Duncan Purtill, Bartlomiej Getta, Anne M. Johnston, Tasman Armytage, Marnie Collins, Kate Mason, Katherine Fielding, Matthew Greenwood, John Gibson, Mark Hertzberg, Matthew Wright, Ian Lewis, John Moore, David Curtis, Jeff SzerGlen Kennedy, David Ritchie

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Abstract

Background/AimsWe sought to determine factors associated with the overall survival from relapse (OSR) of acute myeloid leukaemia (AML) after allogeneic haemopoietic stem cell transplantation (alloHSCT) and the effect of first salvage therapy and subsequent graft-versus-host disease (GVHD) on OSR.

MethodsData on 386 patients from nine Australian centres with relapsed AML post-alloHSCT were collected retrospectively. OSR was calculated using the Kaplan-Meier method. Univariate and multivariate analyses were conducted using the log-rank test and proportional hazards modelling, respectively and a prognostic index for OSR was derived from multivariate modelling.

ResultsOn multivariate analysis, relapse within 6 months (hazard ratio (HR) 2.4, P

ConclusionPatients with AML who relapse beyond 6 months from alloHSCT without prior grade 3-4 acute GVHD have a better outcome from salvage therapy. Salvage treatments employing DCT as the initial treatment of AML relapse confer a survival advantage over CT.

Original languageEnglish
Pages (from-to)276-285
Number of pages10
JournalInternal Medicine Journal
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2018
Externally publishedYes

Cite this

Lim, A. B. M., Curley, C., Fong, C. Y., Bilmon, I., Beligaswatte, A., Purtill, D., Getta, B., Johnston, A. M., Armytage, T., Collins, M., Mason, K., Fielding, K., Greenwood, M., Gibson, J., Hertzberg, M., Wright, M., Lewis, I., Moore, J., Curtis, D., ... Ritchie, D. (2018). Acute myeloid leukaemia relapsing after allogeneic haemopoietic stem cell transplantation: prognostic factors and impact of initial therapy of relapse. Internal Medicine Journal, 48(3), 276-285. https://doi.org/10.1111/imj.13522