Acute Leukemia Presenting in the Pediatric Orbit

Pav Gounder, Siddharth Ogra, Kim Chan, Daisy Bassey-Duke, Linda Okafor, Raghavan Sampath, Simon N. Madge

Research output: Contribution to journalArticlepeer-review


We present a case series to evaluate the clinical features of acute leukemia presenting with primary orbital manifestations. We undertook a retrospective case review of primary orbital presentations of acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) over a 10-year period at two hospital sites (Hereford County Hospital and Leicester Royal Infirmary). Our case series included four patients - two with AML and two with ALL. Patients were young (mean age of four years and five months) at presentation, all with unilateral disease, and presented with orbital signs. Although there was some confusion with the diagnosis at the time of referral, a suspicion of malignancy was made rapidly once ophthalmic review was initiated. All four cases were diagnosed with the assistance of peripheral blood film and bone marrow biopsy, without the need for orbital biopsy. All four cases had resolution of the orbital mass and remain disease-free.
Original languageEnglish
Article number29996
Number of pages7
JournalCureus Journal of Medical Science
Issue number10
Publication statusPublished - 6 Oct 2022
Externally publishedYes


Dive into the research topics of 'Acute Leukemia Presenting in the Pediatric Orbit'. Together they form a unique fingerprint.

Cite this