Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure

Andrew Haynes, Matthew D. Linden, Lauren C. Chasland, Kazunori Nosaka, Andrew Maiorana, Ellen A. Dawson, Lawrence H. Dembo, Louise H. Naylor, Daniel J. Green

    Research output: Contribution to journalArticle

    Abstract

    Evidence-based guidelines recommend exercise therapy for patients with chronic heart failure (CHF). Such patients have increased atherothrombotic risk. Exercise can transiently increase platelet activation and reactivity and decrease vascular function in healthy participants, although data in CHF is scant. Eccentric (ECC) cycling is a novel exercise modality which may be particularly suited to patients with CHF, but the acute impacts of ECC on platelet and vascular function are currently unknown. Our null hypothesis was that ECC and concentric (CON) cycling, performed at matched external workloads, would not induce changes in platelet or vascular function in patients with CHF. Eleven patients with heart failure with reduced ejection fraction (HFrEF) took part in discrete bouts of ECC and CON cycling. Before and immediately after exercise, vascular function was assessed by measuring diameter and flow mediated dilation (FMD) of the brachial artery. Platelet function was measured by the flow cytometric determination of glycoprotein IIb/IIIa activation and granule exocytosis in the presence and absence of platelet agonists. ECC increased baseline artery diameter (pre: 4.0±0.8mm vs post: 4.2±0.7mm, P=0.04) and decreased FMD%. When changes in baseline artery diameter were accounted for the decrease in FMD post-ECC was no longer significant. No changes were apparent after CON. Neither ECC nor CON resulted in changes to any platelet function measures (all P>0.05). These results suggest both ECC and CON cycling at a moderate intensity and short duration can be performed by patients with HFrEF, without detrimental impacts on vascular or platelet function. © 2017 the American Physiological Society

    Original languageEnglish
    Pages (from-to)1418-1424
    Number of pages7
    JournalJournal of Applied Physiology
    Volume122
    Issue number6
    Early online date16 Mar 2017
    DOIs
    Publication statusPublished - 1 Jun 2017

    Fingerprint

    Blood Vessels
    Blood Platelets
    Heart Failure
    Dilatation
    Exercise
    Arteries
    Exercise Therapy
    Platelet Glycoprotein GPIIb-IIIa Complex
    Brachial Artery
    Platelet Activation
    Exocytosis
    Workload
    Healthy Volunteers
    Guidelines

    Cite this

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    title = "Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure",
    abstract = "Evidence-based guidelines recommend exercise therapy for patients with chronic heart failure (CHF). Such patients have increased atherothrombotic risk. Exercise can transiently increase platelet activation and reactivity and decrease vascular function in healthy participants, although data in CHF is scant. Eccentric (ECC) cycling is a novel exercise modality which may be particularly suited to patients with CHF, but the acute impacts of ECC on platelet and vascular function are currently unknown. Our null hypothesis was that ECC and concentric (CON) cycling, performed at matched external workloads, would not induce changes in platelet or vascular function in patients with CHF. Eleven patients with heart failure with reduced ejection fraction (HFrEF) took part in discrete bouts of ECC and CON cycling. Before and immediately after exercise, vascular function was assessed by measuring diameter and flow mediated dilation (FMD) of the brachial artery. Platelet function was measured by the flow cytometric determination of glycoprotein IIb/IIIa activation and granule exocytosis in the presence and absence of platelet agonists. ECC increased baseline artery diameter (pre: 4.0±0.8mm vs post: 4.2±0.7mm, P=0.04) and decreased FMD{\%}. When changes in baseline artery diameter were accounted for the decrease in FMD post-ECC was no longer significant. No changes were apparent after CON. Neither ECC nor CON resulted in changes to any platelet function measures (all P>0.05). These results suggest both ECC and CON cycling at a moderate intensity and short duration can be performed by patients with HFrEF, without detrimental impacts on vascular or platelet function. {\circledC} 2017 the American Physiological Society",
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    Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure. / Haynes, Andrew; Linden, Matthew D.; Chasland, Lauren C.; Nosaka, Kazunori; Maiorana, Andrew; Dawson, Ellen A.; Dembo, Lawrence H.; Naylor, Louise H.; Green, Daniel J.

    In: Journal of Applied Physiology, Vol. 122, No. 6, 01.06.2017, p. 1418-1424.

    Research output: Contribution to journalArticle

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    AU - Haynes, Andrew

    AU - Linden, Matthew D.

    AU - Chasland, Lauren C.

    AU - Nosaka, Kazunori

    AU - Maiorana, Andrew

    AU - Dawson, Ellen A.

    AU - Dembo, Lawrence H.

    AU - Naylor, Louise H.

    AU - Green, Daniel J.

    PY - 2017/6/1

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    N2 - Evidence-based guidelines recommend exercise therapy for patients with chronic heart failure (CHF). Such patients have increased atherothrombotic risk. Exercise can transiently increase platelet activation and reactivity and decrease vascular function in healthy participants, although data in CHF is scant. Eccentric (ECC) cycling is a novel exercise modality which may be particularly suited to patients with CHF, but the acute impacts of ECC on platelet and vascular function are currently unknown. Our null hypothesis was that ECC and concentric (CON) cycling, performed at matched external workloads, would not induce changes in platelet or vascular function in patients with CHF. Eleven patients with heart failure with reduced ejection fraction (HFrEF) took part in discrete bouts of ECC and CON cycling. Before and immediately after exercise, vascular function was assessed by measuring diameter and flow mediated dilation (FMD) of the brachial artery. Platelet function was measured by the flow cytometric determination of glycoprotein IIb/IIIa activation and granule exocytosis in the presence and absence of platelet agonists. ECC increased baseline artery diameter (pre: 4.0±0.8mm vs post: 4.2±0.7mm, P=0.04) and decreased FMD%. When changes in baseline artery diameter were accounted for the decrease in FMD post-ECC was no longer significant. No changes were apparent after CON. Neither ECC nor CON resulted in changes to any platelet function measures (all P>0.05). These results suggest both ECC and CON cycling at a moderate intensity and short duration can be performed by patients with HFrEF, without detrimental impacts on vascular or platelet function. © 2017 the American Physiological Society

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    DO - 10.1152/japplphysiol.01057.2016

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    JO - Journal of applied physiology (Bethesda, Md. : 1985)

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