Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence of Increased 25-Hydroxyvitamin D3 Levels in Male Mice

Shelley Gorman, N.M. Scott, D.H.W. Tan, C.E. Weeden, Robert Tuckey, J.L. Bisley, M.A. Grimbaldeston, Prudence Hart

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator of the immunosuppression that occurs following UV radiation (UVR) exposure. Both UVR and vitamin D drive immune responses towards tolerance by ultimately increasing the suppressive activities of regulatory T cells. To examine a role for UVR-induced vitamin D, vitamin D3-deficient mice were established by dietary vitamin D3 restriction. In comparison to vitamin D3-replete mice, vitamin D3-deficient mice had significantly reduced serum levels of 25-hydroxyvitamin D3 (25(OH)D3,
Original languageEnglish
Pages (from-to)e46006.1-12
JournalPLoS One
Volume7
Issue number9
DOIs
Publication statusPublished - 26 Sep 2012

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25-hydroxycholecalciferol
Calcifediol
cholecalciferol
Cholecalciferol
immunosuppression
Ultraviolet radiation
Immunosuppression
ultraviolet radiation
vitamin D
Vitamin D
Radiation
mice
T-cells
Regulatory T-Lymphocytes
Skin
T-lymphocytes
irradiation
immune response
Irradiation
Serum

Cite this

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Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence of Increased 25-Hydroxyvitamin D3 Levels in Male Mice. / Gorman, Shelley; Scott, N.M.; Tan, D.H.W.; Weeden, C.E.; Tuckey, Robert; Bisley, J.L.; Grimbaldeston, M.A.; Hart, Prudence.

In: PLoS One, Vol. 7, No. 9, 26.09.2012, p. e46006.1-12.

Research output: Contribution to journalArticle

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AU - Gorman, Shelley

AU - Scott, N.M.

AU - Tan, D.H.W.

AU - Weeden, C.E.

AU - Tuckey, Robert

AU - Bisley, J.L.

AU - Grimbaldeston, M.A.

AU - Hart, Prudence

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AB - Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator of the immunosuppression that occurs following UV radiation (UVR) exposure. Both UVR and vitamin D drive immune responses towards tolerance by ultimately increasing the suppressive activities of regulatory T cells. To examine a role for UVR-induced vitamin D, vitamin D3-deficient mice were established by dietary vitamin D3 restriction. In comparison to vitamin D3-replete mice, vitamin D3-deficient mice had significantly reduced serum levels of 25-hydroxyvitamin D3 (25(OH)D3,

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