Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence of Increased 25-Hydroxyvitamin D3 Levels in Male Mice

Shelley Gorman, N.M. Scott, D.H.W. Tan, C.E. Weeden, Robert Tuckey, J.L. Bisley, M.A. Grimbaldeston, Prudence Hart

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator of the immunosuppression that occurs following UV radiation (UVR) exposure. Both UVR and vitamin D drive immune responses towards tolerance by ultimately increasing the suppressive activities of regulatory T cells. To examine a role for UVR-induced vitamin D, vitamin D3-deficient mice were established by dietary vitamin D3 restriction. In comparison to vitamin D3-replete mice, vitamin D3-deficient mice had significantly reduced serum levels of 25-hydroxyvitamin D3 (25(OH)D3,
Original languageEnglish
Pages (from-to)e46006.1-12
JournalPLoS One
Volume7
Issue number9
DOIs
Publication statusPublished - 26 Sep 2012

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