Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: A randomized trial

Aidilla Mubarak, Catherine P. Bondonno, Alex H. Liu, Michael J. Considine, Lisa Rich, Emilie Mas, Kevin D. Croft, Jonathan M. Hodgson

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    Abstract

    There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide. Our aim was to investigate the acute effects of chlorogenic acid, an important dietary phenolic acid present in coffee (400 mg, equivalent to 2 cups of coffee), on nitric oxide status, endothelial function, and blood pressure. Healthy men and women (n = 23) were recruited to a randomized, double-blind, placebo-controlled, crossover trial. Chlorogenic acid resulted in significantly higher plasma concentrations of chlorogenic acid (P <0.001). Relative to control, the mean post-treatment systolic blood pressure (−2.41 mmHg, 95% CI: −0.03, −4.78; P = 0.05) and diastolic blood pressure (−1.53 mmHg, 95% CI: −0.05, −3.01; P = 0.04) were significantly lower with chlorogenic acid. Markers of nitric oxide status (P > 0.10) and the measure of endothelial function (P = 0.60) were not significantly influenced. Chlorogenic acid can lower blood pressure acutely, an effect that, if sustained, would benefit cardiovascular health.
    Original languageEnglish
    Pages (from-to)9130-9136
    JournalJournal of Agricultural and Food Chemistry
    Volume60
    Issue number36
    DOIs
    Publication statusPublished - 20 Aug 2012

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