TY - JOUR
T1 - Activity-based proteomics probes for carbohydrate-processing enzymes: Current trends and future outlook
AU - Stubbs, Keith
PY - 2014
Y1 - 2014
N2 - Carbohydrate-processing enzymes are gaining more attention due to their roles in health and disease as these enzymes are involved in the construction and deconstruction of vast arrays of glycan structures. As a result, the development of methods to identify these enzymes in complex biological systems is of increasing interest. Activity-based proteomics probes (ABPPs) are increasingly being used in glycobiology to detect and identify functionally related proteins (and homologues) within a biological system. This review will describe the design of activity-based proteomics probes, provide examples of compounds that have been used to profile activity in the area of carbohydrate-processing enzymes, and give some future perspectives. © 2014 Elsevier Ltd. All rights reserved.
AB - Carbohydrate-processing enzymes are gaining more attention due to their roles in health and disease as these enzymes are involved in the construction and deconstruction of vast arrays of glycan structures. As a result, the development of methods to identify these enzymes in complex biological systems is of increasing interest. Activity-based proteomics probes (ABPPs) are increasingly being used in glycobiology to detect and identify functionally related proteins (and homologues) within a biological system. This review will describe the design of activity-based proteomics probes, provide examples of compounds that have been used to profile activity in the area of carbohydrate-processing enzymes, and give some future perspectives. © 2014 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.carres.2014.02.023
DO - 10.1016/j.carres.2014.02.023
M3 - Review article
C2 - 24680833
SN - 0008-6215
VL - 390
SP - 9
EP - 19
JO - Carbohydrate Research
JF - Carbohydrate Research
IS - 1
ER -