Activin A exerts both pro- and anti-inflammatory effects on human term gestational tissues

Jeffrey Keelan, RL Zhou, MD Mitchell

    Research output: Contribution to journalArticle

    63 Citations (Scopus)

    Abstract

    There is a growing appreciation of the importance of activin as a modulator of immune function. The aim of the present study was to determine whether activin A exerts any effects on cytokine and prostaglandin (PG) production by the tissues of pregnancy. Explant cultures were established for amnion, choriodecidual and placental tissues derived from pregnancies delivered at term by Caesarean section (n=5 placentae). Explants were treated with activin A (0.5, 5 and 50 ng/ml) in serum-free Ham's F12/DME media for 24h (n=3-4 replicates). Production rates of interleukin (IL)-1 beta, IL-6, IL-8, tumour necrosis factor-alpha (TNF-alpha) and PGE(2) were determined using immunoassay. Differences between treatment groups were analysed by ANOVA followed by Dunnett's test; P
    Original languageEnglish
    Pages (from-to)38-43
    JournalPlacenta
    Volume21
    DOIs
    Publication statusPublished - 2000

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