Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection

A.J. Rodger, Z. Fox, J.D. Lundgren, L.H. Kuller, C. Boesecke, D. Gey, A. Skoutelis, M.B. Goetz, A.N. Phillips, [No Value] Insight Study Group, Martyn French

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    Abstract

    BackgroundActivation and coagulation biomarkers were measured within the Strategies for Management of Antiretroviral Therapy (SMART) trial. Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)–positive patients were examinedMethodsInflammatory (high-sensitivity C-reactive protein [hsCRP], interleukin-6 [IL–6], amyloid-A, and amyloid-P) and coagulation (D-dimer and prothrombin-fragment 1+2) markers were determined. Conditional logistic regression analyses were used to assess associations between these biomarkers and risk of ODResultsThe 91 patients who developed an OD were matched to 182 control subjects. Patients with an hsCRP level ⩾5 μg/mL at baseline had a 3.5 higher odds of OD (95% confidence interval [CI], 1.5–8.1) than did those with an hsCRP level
    Original languageEnglish
    Pages (from-to)973-983
    JournalThe Journal of infectious diseases
    Volume200
    Issue number6
    DOIs
    Publication statusPublished - 2009

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