Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection

A.J. Rodger; Z. Fox; J.D. Lundgren; L.H. Kuller; C. Boesecke; D. Gey; A. Skoutelis; M.B. Goetz; A.N. Phillips; [No Value] Insight Study Group; Martyn French

doi:10.1086/605447

Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection

A.J. Rodger, Z. Fox, J.D. Lundgren, L.H. Kuller, C. Boesecke, D. Gey, A. Skoutelis, M.B. Goetz, A.N. Phillips, [No Value] Insight Study Group, Martyn French

Research output: Contribution to journal › Article

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Abstract

BackgroundActivation and coagulation biomarkers were measured within the Strategies for Management of Antiretroviral Therapy (SMART) trial. Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)–positive patients were examinedMethodsInflammatory (high-sensitivity C-reactive protein [hsCRP], interleukin-6 [IL–6], amyloid-A, and amyloid-P) and coagulation (D-dimer and prothrombin-fragment 1+2) markers were determined. Conditional logistic regression analyses were used to assess associations between these biomarkers and risk of ODResultsThe 91 patients who developed an OD were matched to 182 control subjects. Patients with an hsCRP level ⩾5 μg/mL at baseline had a 3.5 higher odds of OD (95% confidence interval [CI], 1.5–8.1) than did those with an hsCRP level

Original language	English
Pages (from-to)	973-983
Journal	The Journal of infectious diseases
Volume	200
Issue number	6
DOIs	https://doi.org/10.1086/605447
Publication status	Published - 2009

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Rodger, A. J., Fox, Z., Lundgren, J. D., Kuller, L. H., Boesecke, C., Gey, D., Skoutelis, A., Goetz, M. B., Phillips, A. N., Insight Study Group, N. V., & French, M. (2009). Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection. The Journal of infectious diseases, 200(6), 973-983. https://doi.org/10.1086/605447

Rodger, A.J. ; Fox, Z. ; Lundgren, J.D. ; Kuller, L.H. ; Boesecke, C. ; Gey, D. ; Skoutelis, A. ; Goetz, M.B. ; Phillips, A.N. ; Insight Study Group, [No Value] ; French, Martyn. / Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection. In: The Journal of infectious diseases. 2009 ; Vol. 200, No. 6. pp. 973-983.

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title = "Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection",

abstract = "BackgroundActivation and coagulation biomarkers were measured within the Strategies for Management of Antiretroviral Therapy (SMART) trial. Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)–positive patients were examinedMethodsInflammatory (high-sensitivity C-reactive protein [hsCRP], interleukin-6 [IL–6], amyloid-A, and amyloid-P) and coagulation (D-dimer and prothrombin-fragment 1+2) markers were determined. Conditional logistic regression analyses were used to assess associations between these biomarkers and risk of ODResultsThe 91 patients who developed an OD were matched to 182 control subjects. Patients with an hsCRP level ⩾5 μg/mL at baseline had a 3.5 higher odds of OD (95% confidence interval [CI], 1.5–8.1) than did those with an hsCRP level",

author = "A.J. Rodger and Z. Fox and J.D. Lundgren and L.H. Kuller and C. Boesecke and D. Gey and A. Skoutelis and M.B. Goetz and A.N. Phillips and {Insight Study Group}, {[No Value]} and Martyn French",

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Rodger, AJ, Fox, Z, Lundgren, JD, Kuller, LH, Boesecke, C, Gey, D, Skoutelis, A, Goetz, MB, Phillips, AN, Insight Study Group, NV & French, M 2009, 'Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection', The Journal of infectious diseases, vol. 200, no. 6, pp. 973-983. https://doi.org/10.1086/605447

Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection. / Rodger, A.J.; Fox, Z.; Lundgren, J.D.; Kuller, L.H.; Boesecke, C.; Gey, D.; Skoutelis, A.; Goetz, M.B.; Phillips, A.N.; Insight Study Group, [No Value]; French, Martyn.

In: The Journal of infectious diseases, Vol. 200, No. 6, 2009, p. 973-983.

Research output: Contribution to journal › Article

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T1 - Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection

AU - Rodger, A.J.

AU - Fox, Z.

AU - Lundgren, J.D.

AU - Kuller, L.H.

AU - Boesecke, C.

AU - Gey, D.

AU - Skoutelis, A.

AU - Goetz, M.B.

AU - Phillips, A.N.

AU - Insight Study Group, [No Value]

AU - French, Martyn

PY - 2009

Y1 - 2009

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AB - BackgroundActivation and coagulation biomarkers were measured within the Strategies for Management of Antiretroviral Therapy (SMART) trial. Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)–positive patients were examinedMethodsInflammatory (high-sensitivity C-reactive protein [hsCRP], interleukin-6 [IL–6], amyloid-A, and amyloid-P) and coagulation (D-dimer and prothrombin-fragment 1+2) markers were determined. Conditional logistic regression analyses were used to assess associations between these biomarkers and risk of ODResultsThe 91 patients who developed an OD were matched to 182 control subjects. Patients with an hsCRP level ⩾5 μg/mL at baseline had a 3.5 higher odds of OD (95% confidence interval [CI], 1.5–8.1) than did those with an hsCRP level

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