Erfassung der Internalisierung von GPCRs mit CRISPR/Cas9

Translated title of the contribution: Acquisition of the internalization of GPCRs with CRISPR / Cas9

Andrea Krumm, Carl White, Kevin Pfleger

Research output: Contribution to journalArticle

Abstract

Receptors are prevalent drug targets as they translate signals from outside the cell to cellular reactions. In drug finding and characterization it is not only required to measure ligand binding, but just as well subsequent regulatory steps including desensitizing protein interactions. Here, we show how CRISPR/Cas9 allowed endogenous expression of a G-protein coupled receptor (GPCR) and how that was used to study protein inter -actions and internalization of a cancer progressing receptor.
Translated title of the contribution Acquisition of the internalization of GPCRs with CRISPR / Cas9
Original languageGerman
Pages (from-to)616-617
Number of pages2
JournalBioSpektrum
Volume24
Issue number6
DOIs
Publication statusPublished - 1 Oct 2018

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