Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis

Immunology and Microbiology

• Cancer Cell 50%
• Cell Metabolism 50%
• DNA Mutation 100%
• DNA Sequence 50%
• Drug Therapy 50%
• G1 Phase Cell Cycle Checkpoint 50%
• Gene Expression Assay 50%
• Glutamine 50%
• Induced Resistance 50%
• Metabolite 50%
• Oxygen Consumption 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Dactolisib 100%
• Epidermal Growth Factor Receptor 50%
• Glucose Transporter 1 25%
• Glutamine 25%
• Lactic Acid 25%
• Lung Cancer 25%
• Malignant Neoplasm 25%
• Mammalian Target of Rapamycin Inhibitor 100%
• Mitochondrial DNA 100%
• Pharmacotherapy 25%
• Protein Kinase B 25%
• Reactive Oxygen Metabolite 25%
• Transcriptome 25%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 16%
• Cell Metabolism 16%
• DNA Mutation 100%
• DNA Sequence 16%
• Drug Therapy 16%
• Epidermal Growth Factor Receptor 33%
• G1/S Transition 16%
• Gene Expression Profiling 16%
• GLUT1 16%
• Glutamine 16%
• Induced Resistance 16%
• Mammalian Target of Rapamycin 100%
• Metabolite 16%
• Mitochondrial DNA 100%
• Oxygen Consumption 16%
• Protein Kinase B 16%