Accelerated low-intensity rTMS does not rescue anxiety behaviour or abnormal connectivity in young adult rats following chronic restraint stress

Lauren Hennessy, Bhedita Jaya Seewoo, Liz Jaeschke-Angi, Leah Mackie, Abbey Figliomeni, Yasmin Arena-Foster, Sarah J. Etherington, Sarah Dunlop, Paul E. Croarkin, Jennifer Rodger

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Currently approved repetitive transcranial magnetic stimulation (rTMS) protocols for the treatment of major depressive disorder (MDD) involve once-daily (weekday) stimulation sessions, with 10 Hz or intermittent theta burst stimulation (iTBS) frequencies, over 4–6 weeks. Recently, accelerated treatment protocols (multiple daily stimulation sessions for 1–2 weeks) have been increasingly studied to optimize rTMS treatments. Accelerated protocols might confer unique advantages for adolescents and young adults but there are many knowledge gaps related to dosing in this age group. Off-label, clinical practice frequently outpaces solid evidence as rigorous clinical trials require substantial time and resources. Murine models present an opportunity for high throughput dose finding studies to focus subsequent clinical trials in humans. This project investigated the brain and behavioural effects of an accelerated low …
Original languageEnglish
Article number100104
JournalNeuroimage: Reports
Volume2
Issue number3
DOIs
Publication statusPublished - 1 Sept 2022

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