TY - JOUR
T1 - Accelerated low-intensity rTMS does not rescue anxiety behaviour or abnormal connectivity in young adult rats following chronic restraint stress
AU - Hennessy, Lauren
AU - Seewoo, Bhedita Jaya
AU - Jaeschke-Angi, Liz
AU - Mackie, Leah
AU - Figliomeni, Abbey
AU - Arena-Foster, Yasmin
AU - Etherington, Sarah J.
AU - Dunlop, Sarah
AU - Croarkin, Paul E.
AU - Rodger, Jennifer
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Currently approved repetitive transcranial magnetic stimulation (rTMS) protocols for the treatment of major depressive disorder (MDD) involve once-daily (weekday) stimulation sessions, with 10 Hz or intermittent theta burst stimulation (iTBS) frequencies, over 4–6 weeks. Recently, accelerated treatment protocols (multiple daily stimulation sessions for 1–2 weeks) have been increasingly studied to optimize rTMS treatments. Accelerated protocols might confer unique advantages for adolescents and young adults but there are many knowledge gaps related to dosing in this age group. Off-label, clinical practice frequently outpaces solid evidence as rigorous clinical trials require substantial time and resources. Murine models present an opportunity for high throughput dose finding studies to focus subsequent clinical trials in humans. This project investigated the brain and behavioural effects of an accelerated low …
AB - Currently approved repetitive transcranial magnetic stimulation (rTMS) protocols for the treatment of major depressive disorder (MDD) involve once-daily (weekday) stimulation sessions, with 10 Hz or intermittent theta burst stimulation (iTBS) frequencies, over 4–6 weeks. Recently, accelerated treatment protocols (multiple daily stimulation sessions for 1–2 weeks) have been increasingly studied to optimize rTMS treatments. Accelerated protocols might confer unique advantages for adolescents and young adults but there are many knowledge gaps related to dosing in this age group. Off-label, clinical practice frequently outpaces solid evidence as rigorous clinical trials require substantial time and resources. Murine models present an opportunity for high throughput dose finding studies to focus subsequent clinical trials in humans. This project investigated the brain and behavioural effects of an accelerated low …
U2 - 10.1016/j.ynirp.2022.100104
DO - 10.1016/j.ynirp.2022.100104
M3 - Article
C2 - 36277329
SN - 2666-9560
VL - 2
JO - Neuroimage: Reports
JF - Neuroimage: Reports
IS - 3
M1 - 100104
ER -