Academic performance in children of mothers with schizophrenia and other severe mental illness, and risk for subsequent development of psychosis: A population-based study

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Abstract

Objective: We examined the academic performance at age 12 years of children of mothers diagnosed with schizophrenia or other severe mental illness using a large whole-population birth cohort born in Western Australia. We investigated the association between academic performance and the subsequent development of psychotic illness. Method: The sample comprised 3169 children of mothers with severe mental illness (schizophrenia, bipolar disorder, unipolar major depression, delusional disorder or other psychoses; ICD-9 codes 295-298), and 88 353 children of comparison mothers without known psychiatric morbidity. Academic performance of children was indexed on a mandatory state-wide test of reading, spelling, writing and numeracy. Results: A larger proportion of children (43.1%) of mothers with severe mental illness performed below the acceptable standard than the reference group (30.3%; children of mothers with no known severe mental illness). After adjusting for covariates, children of mothers with any severe mental illness were more likely than the reference group to perform below-benchmark on all domains except reading. For all children, poor spelling was associated with the later development of psychosis, but particularly for those at familial risk for severe mental illness (hazard ratio [HR] = 1.81; 95% CI for HR = 1.21, 2.72). Conclusions: Children of mothers with a severe mental illness are at increased risk for sub-standard academic achievement at age 12 years, placing these children at disadvantage for the transition to secondary school. For children with familial risk for severe mental illness, very poor spelling skills at age 12 years may be an indicator of risk for later psychotic disorder.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalSchizophrenia Bulletin
Volume43
Issue number1
Early online date30 Apr 2016
DOIs
Publication statusPublished - 1 Jan 2017

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Psychotic Disorders
Schizophrenia
Mothers
Population
International Classification of Diseases
Reading
Paranoid Schizophrenia
Benchmarking
Western Australia
Depressive Disorder
Bipolar Disorder
Psychiatry
Parturition
Morbidity

Cite this

@article{f2eef8358f6a4033aa5f94e9921ff551,
title = "Academic performance in children of mothers with schizophrenia and other severe mental illness, and risk for subsequent development of psychosis: A population-based study",
abstract = "Objective: We examined the academic performance at age 12 years of children of mothers diagnosed with schizophrenia or other severe mental illness using a large whole-population birth cohort born in Western Australia. We investigated the association between academic performance and the subsequent development of psychotic illness. Method: The sample comprised 3169 children of mothers with severe mental illness (schizophrenia, bipolar disorder, unipolar major depression, delusional disorder or other psychoses; ICD-9 codes 295-298), and 88 353 children of comparison mothers without known psychiatric morbidity. Academic performance of children was indexed on a mandatory state-wide test of reading, spelling, writing and numeracy. Results: A larger proportion of children (43.1{\%}) of mothers with severe mental illness performed below the acceptable standard than the reference group (30.3{\%}; children of mothers with no known severe mental illness). After adjusting for covariates, children of mothers with any severe mental illness were more likely than the reference group to perform below-benchmark on all domains except reading. For all children, poor spelling was associated with the later development of psychosis, but particularly for those at familial risk for severe mental illness (hazard ratio [HR] = 1.81; 95{\%} CI for HR = 1.21, 2.72). Conclusions: Children of mothers with a severe mental illness are at increased risk for sub-standard academic achievement at age 12 years, placing these children at disadvantage for the transition to secondary school. For children with familial risk for severe mental illness, very poor spelling skills at age 12 years may be an indicator of risk for later psychotic disorder.",
keywords = "Academic performance, At-risk, Familial risk, Genetic risk, Linked data, Neurocognition, Population, Psychiatric disorder, Psychosis, Schizophrenia",
author = "Ashleigh Lin and {Di Prinzio}, Patricia and Deidra Young and Peter Jacoby and Andrew Whitehouse and Flavie Waters and Assen Jablensky and Morgan, {Vera A.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1093/schbul/sbw042",
language = "English",
volume = "43",
pages = "205--213",
journal = "Schizophrenia Bulletin",
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T1 - Academic performance in children of mothers with schizophrenia and other severe mental illness, and risk for subsequent development of psychosis

T2 - A population-based study

AU - Lin, Ashleigh

AU - Di Prinzio, Patricia

AU - Young, Deidra

AU - Jacoby, Peter

AU - Whitehouse, Andrew

AU - Waters, Flavie

AU - Jablensky, Assen

AU - Morgan, Vera A.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective: We examined the academic performance at age 12 years of children of mothers diagnosed with schizophrenia or other severe mental illness using a large whole-population birth cohort born in Western Australia. We investigated the association between academic performance and the subsequent development of psychotic illness. Method: The sample comprised 3169 children of mothers with severe mental illness (schizophrenia, bipolar disorder, unipolar major depression, delusional disorder or other psychoses; ICD-9 codes 295-298), and 88 353 children of comparison mothers without known psychiatric morbidity. Academic performance of children was indexed on a mandatory state-wide test of reading, spelling, writing and numeracy. Results: A larger proportion of children (43.1%) of mothers with severe mental illness performed below the acceptable standard than the reference group (30.3%; children of mothers with no known severe mental illness). After adjusting for covariates, children of mothers with any severe mental illness were more likely than the reference group to perform below-benchmark on all domains except reading. For all children, poor spelling was associated with the later development of psychosis, but particularly for those at familial risk for severe mental illness (hazard ratio [HR] = 1.81; 95% CI for HR = 1.21, 2.72). Conclusions: Children of mothers with a severe mental illness are at increased risk for sub-standard academic achievement at age 12 years, placing these children at disadvantage for the transition to secondary school. For children with familial risk for severe mental illness, very poor spelling skills at age 12 years may be an indicator of risk for later psychotic disorder.

AB - Objective: We examined the academic performance at age 12 years of children of mothers diagnosed with schizophrenia or other severe mental illness using a large whole-population birth cohort born in Western Australia. We investigated the association between academic performance and the subsequent development of psychotic illness. Method: The sample comprised 3169 children of mothers with severe mental illness (schizophrenia, bipolar disorder, unipolar major depression, delusional disorder or other psychoses; ICD-9 codes 295-298), and 88 353 children of comparison mothers without known psychiatric morbidity. Academic performance of children was indexed on a mandatory state-wide test of reading, spelling, writing and numeracy. Results: A larger proportion of children (43.1%) of mothers with severe mental illness performed below the acceptable standard than the reference group (30.3%; children of mothers with no known severe mental illness). After adjusting for covariates, children of mothers with any severe mental illness were more likely than the reference group to perform below-benchmark on all domains except reading. For all children, poor spelling was associated with the later development of psychosis, but particularly for those at familial risk for severe mental illness (hazard ratio [HR] = 1.81; 95% CI for HR = 1.21, 2.72). Conclusions: Children of mothers with a severe mental illness are at increased risk for sub-standard academic achievement at age 12 years, placing these children at disadvantage for the transition to secondary school. For children with familial risk for severe mental illness, very poor spelling skills at age 12 years may be an indicator of risk for later psychotic disorder.

KW - Academic performance

KW - At-risk

KW - Familial risk

KW - Genetic risk

KW - Linked data

KW - Neurocognition

KW - Population

KW - Psychiatric disorder

KW - Psychosis

KW - Schizophrenia

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U2 - 10.1093/schbul/sbw042

DO - 10.1093/schbul/sbw042

M3 - Article

VL - 43

SP - 205

EP - 213

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 1

ER -