TY - JOUR
T1 - Abnormal glucose regulation in an Australian acute coronary syndrome population: A prospective study
AU - Chih, S.
AU - Mcquillan, Brendan
AU - Kaye, J.
AU - Beilby, John
AU - Hung, Joe
PY - 2008
Y1 - 2008
N2 - Background: Abnormal glucose regulation (AGR) is common and an adverse risk factor in patients presenting with acute coronary syndromes (ACS).Methods: We prospectively evaluated the prevalence of AGR in 300 ACS patients. Fasting blood glucose (BGL), glycated haemoglobin (HbA1c) and urinary albumin creatinine ratio (ACR) were performed. Patients without diabetes completed an oral glucose tolerance test (OGTT) >= 4 weeks post-discharge.Results: On admission, AGR prevalence was 60%; 32% (n = 94) with diabetes and 28% (n = 83) with IFG. OGTT completed in 157 patients, detected new diabetes in 5% (n = 8), IGT in 24% (n = 37), and IFG in 6% (n = 10). In 91 patients with normal admission fasting BGL, 25% (n = 23) had AGR on OGTT. Conversely, in 62 patients with admission IFG, 50% (n = 31) had a normal OGTT. Patients with versus those without AGR on OGTT had higher adjusted geometric mean HbA1c (5.92; 95% CI 5.81-6.02 vs. 5.66; 95% CI, 5.59-5.74, P = 0.001) and urinary ACR (1.38; 95% CI, 0.99-1.91 vs. 0.74; 95% CI, 0.58-0.94, P = 0.003) levels.Conclusions: AGR is present in the majority of ACS patients and unrecognised in up to half of cases. OGTT improves the detection of AGR. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.
AB - Background: Abnormal glucose regulation (AGR) is common and an adverse risk factor in patients presenting with acute coronary syndromes (ACS).Methods: We prospectively evaluated the prevalence of AGR in 300 ACS patients. Fasting blood glucose (BGL), glycated haemoglobin (HbA1c) and urinary albumin creatinine ratio (ACR) were performed. Patients without diabetes completed an oral glucose tolerance test (OGTT) >= 4 weeks post-discharge.Results: On admission, AGR prevalence was 60%; 32% (n = 94) with diabetes and 28% (n = 83) with IFG. OGTT completed in 157 patients, detected new diabetes in 5% (n = 8), IGT in 24% (n = 37), and IFG in 6% (n = 10). In 91 patients with normal admission fasting BGL, 25% (n = 23) had AGR on OGTT. Conversely, in 62 patients with admission IFG, 50% (n = 31) had a normal OGTT. Patients with versus those without AGR on OGTT had higher adjusted geometric mean HbA1c (5.92; 95% CI 5.81-6.02 vs. 5.66; 95% CI, 5.59-5.74, P = 0.001) and urinary ACR (1.38; 95% CI, 0.99-1.91 vs. 0.74; 95% CI, 0.58-0.94, P = 0.003) levels.Conclusions: AGR is present in the majority of ACS patients and unrecognised in up to half of cases. OGTT improves the detection of AGR. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.
U2 - 10.1016/j.diabres.2008.04.026
DO - 10.1016/j.diabres.2008.04.026
M3 - Article
C2 - 18565611
VL - 81
SP - 303
EP - 309
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
ER -
