[Truncated abstract] Procalcitonin has been shown to be useful in separating infection from non-infective disorders. However, infection is often paralleled by tissue inflammation. Most studies supporting the use of procalcitonin were confounded by more significant inflammation in the infection group. Few studies have examined the usefulness of procalcitonin when adjusted for inflammation.Pleural inflammation underlies the development of most exudative effusions including pleural infection and malignancy. Pleurodesis, often used to treat effusions, involves provocation of intense aseptic pleural inflammation. We conducted a two-part proof-of-concept study to test the specificity of procalcitonin in differentiating infection using cohorts of patients with pleural effusions of infective and non-infective etiologies, as well as subjects undergoing pleurodesis...
Mccann, F. J., Chapman, S. J., Yu, W. C., Maskell, N. A., Davies, R. J. O., & Lee, G. (2012). Ability of procalcitonin to discriminate infection from non-infective inflammation using two pleural disease settings. PLoS One, 7(12), 6pp. https://doi.org/10.1371/journal.pone.0049894