Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers

Peter Richmond; R. Borrow; D. Goldblatt; J. Findlow; S. Martin; R. Morris; K. Cartwright; E. Miller

doi:10.1086/317646

Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers

Peter Richmond, R. Borrow, D. Goldblatt, J. Findlow, S. Martin, R. Morris, K. Cartwright, E. Miller

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Abstract

To test for immunologic memory after a single dose of meningococcal C conjugate (MCC) vaccine in toddlers, 226 children 12-18 months old were randomized to receive 1 of 3 MCC vaccines, with a C polysaccharide booster 6 months later. The protein conjugate was diphtheria mutant toxoid in 2 vaccines (MCC-CRM197) and was tetanus toxoid in the third (MCC-TT). One month after the MCC vaccines, 91%-100% of children had serum bactericidal antibody (SBA) titers greater than or equal to8, and 89%-100% had a greater than or equal to4-fold increase. Geometric mean titer (GMT) increased from

Original language	English
Pages (from-to)	160-163
Journal	Journal of Infectious Diseases
Volume	183
DOIs	https://doi.org/10.1086/317646
Publication status	Published - 2001

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abstract = "To test for immunologic memory after a single dose of meningococcal C conjugate (MCC) vaccine in toddlers, 226 children 12-18 months old were randomized to receive 1 of 3 MCC vaccines, with a C polysaccharide booster 6 months later. The protein conjugate was diphtheria mutant toxoid in 2 vaccines (MCC-CRM197) and was tetanus toxoid in the third (MCC-TT). One month after the MCC vaccines, 91%-100% of children had serum bactericidal antibody (SBA) titers greater than or equal to8, and 89%-100% had a greater than or equal to4-fold increase. Geometric mean titer (GMT) increased from",

author = "Peter Richmond and R. Borrow and D. Goldblatt and J. Findlow and S. Martin and R. Morris and K. Cartwright and E. Miller",

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doi = "10.1086/317646",

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T1 - Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers

AU - Richmond, Peter

AU - Borrow, R.

AU - Goldblatt, D.

AU - Findlow, J.

AU - Martin, S.

AU - Morris, R.

AU - Cartwright, K.

AU - Miller, E.

PY - 2001

Y1 - 2001

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AB - To test for immunologic memory after a single dose of meningococcal C conjugate (MCC) vaccine in toddlers, 226 children 12-18 months old were randomized to receive 1 of 3 MCC vaccines, with a C polysaccharide booster 6 months later. The protein conjugate was diphtheria mutant toxoid in 2 vaccines (MCC-CRM197) and was tetanus toxoid in the third (MCC-TT). One month after the MCC vaccines, 91%-100% of children had serum bactericidal antibody (SBA) titers greater than or equal to8, and 89%-100% had a greater than or equal to4-fold increase. Geometric mean titer (GMT) increased from

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DO - 10.1086/317646

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SN - 0022-1899

VL - 183

SP - 160

EP - 163

JO - Journal Infectious Diseases

JF - Journal Infectious Diseases

ER -

Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers

Abstract

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