Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers

Peter Richmond, R. Borrow, D. Goldblatt, J. Findlow, S. Martin, R. Morris, K. Cartwright, E. Miller

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    Abstract

    To test for immunologic memory after a single dose of meningococcal C conjugate (MCC) vaccine in toddlers, 226 children 12-18 months old were randomized to receive 1 of 3 MCC vaccines, with a C polysaccharide booster 6 months later. The protein conjugate was diphtheria mutant toxoid in 2 vaccines (MCC-CRM197) and was tetanus toxoid in the third (MCC-TT). One month after the MCC vaccines, 91%-100% of children had serum bactericidal antibody (SBA) titers greater than or equal to8, and 89%-100% had a greater than or equal to4-fold increase. Geometric mean titer (GMT) increased from
    Original languageEnglish
    Pages (from-to)160-163
    JournalJournal of Infectious Diseases
    Volume183
    DOIs
    Publication statusPublished - 2001

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