Projects per year
Abstract
OBJECTIVE: Examine if two inexpensive measures of atherosclerotic vascular diseases (ASVD), abdominal aortic calcification (AAC) and high-sensitivity cardiac troponin I (hs-cTnI) provide complementary information for 10-year ASVD mortality and all-cause mortality risk in older women.
METHODS: 908 community-dwelling women without prevalent ASVD (≥75 years) were followed-up between 2003 and 2013. AAC and plasma hs-cTnI measures were obtained in 2003. AAC was assessed on lateral spine images using a semiquantitative method (AAC24). Linked health records were used for mortality outcomes.
RESULTS: Mean±SD age was 79.9±2.6 years. 276 (30.4%) women died during follow-up, including 138 (15.2%) ASVD-related deaths. AAC24 and hs-cTnI were independently associated with ASVD and all-cause mortality (p<0.001). The cohort was dichotomised into four groups: (1) low AAC24 (AAC24: 0 or 1) and <median hs-cTnI (n=163, referent), (2) moderate-extensive AAC24 (AAC24:>1) and <median hs-cTnI (n=280), (3) low AAC24 and ≥median hs-cTnI (n=148) and (4) moderate-extensive AAC24 and ≥median hs-cTnI (n=317). Compared with the referent group, a stepwise increase in relative hazard (HR (95% CI)) for ASVD mortality was seen at 2.39 (1.05 to 5.46), 3.18 (1.35 to 7.79) and 5.38 (2.44 to 11.85), respectively. A similar associations were observed for all-cause mortality, at 1.58 (0.99-2.52), 2.38 (1.46-3.89) and 3.02 (1.93-4.72), respectively (all p<0.05).
CONCLUSION: Higher AAC and elevated hs-cTnI were associated with higher risk of ASVD mortality and all-cause mortality, independent of each other. Stratifying by moderate to extensive AAC and elevated hs-cTnI identified women at very high risk. Further studies investigating whether combining factors may improve risk prediction are needed.
TRIAL REGISTRATION NUMBER: ACTRN12617000640303.
Original language | English |
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Pages (from-to) | 1274-1280 |
Number of pages | 7 |
Journal | Heart (British Cardiac Society) |
Volume | 108 |
Issue number | 16 |
Early online date | 24 Dec 2021 |
DOIs | |
Publication status | Published - Aug 2022 |
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Dive into the research topics of 'Abdominal aortic calcification, cardiac troponin I and atherosclerotic vascular disease mortality in older women'. Together they form a unique fingerprint.Projects
- 3 Finished
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Determinants of Musculoskeletal and Other Diseases, Health Service Utilisation and Mortality in a Cohort of Older Women
Zhu, K. (Investigator 01), Prince, R. (Investigator 02), Flicker, L. (Investigator 03) & Mukhtar, S. (Investigator 04)
NHMRC National Health and Medical Research Council
31/12/08 → 31/12/13
Project: Research
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Environmental and Metabolic Influences on Musculoskeletal and other Diseases in a Cohort of Elderly Women
Prince, R. (Chief Investigator), Devine, A. (Chief Investigator), Thompson, P. (Chief Investigator), Dhaliwal, S. S. (Chief Investigator) & Dick, I. (Chief Investigator)
1/01/04 → 31/12/08
Project: Research
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Extension of the Calcium Intake Fracture Outcome Study
Prince, R. (Chief Investigator), Devine, A. (Chief Investigator), Dhaliwal, S. S. (Chief Investigator) & Dick, I. (Chief Investigator)
1/01/03 → 31/12/04
Project: Research