A voxel-based morphometry study of temporal lobe gray matter reductions in Alzheimer's disease

G.F. Busatto, G.E.J. Garrido, Osvaldo Almeida, C.C. Castro, C.H.P. Camargo, C.G. Cid, C.A. Buchpiguel, S. Furuie, C.M. Bottino

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    169 Citations (Scopus)

    Abstract

    Several MRI studies have reported reductions in temporal lobe volumes in Alzheimer’s disease (AD). Measures have been usually obtained with regions-of-interest (ROI) drawn manually on selected medial and lateral portions of the temporal lobes, with variable choices of anatomical borders across different studies. We used the fully automated voxel-based morphometry (VBM) approach to investigate gray matter abnormalities over the entire extension of the temporal lobe in 14 AD patients (MMSE 14–25) and 14 healthy controls. Foci of significantly reduced gray matter volume in AD patients were detected in both medial and lateral temporal regions, most significantly in the right and left posterior parahippocampal gyri and the left posterior inferior temporal gyrus/fusiform gyrus (P
    Original languageEnglish
    Pages (from-to)221-231
    JournalNeurobiology of Aging
    Volume24
    Issue number2
    DOIs
    Publication statusPublished - 2003

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