A variant in LDLR is associated with abdominal aortic aneurysm

D.T. Bradley; A.E. Hughes; S.A. Badger; G.T. Jones; S.C. Harrison; B.J. Wright; S.J. Bumpstead; A.F. Baas; S. Grétarsdóttir; K.G. Burnand; A.H. Child; R.E. Clough; G.W. Cockerill; H.M. Hafez; D.J.A. Scott; R.A.S. Ariëns; A.B. Johnson; S. Sohrabi; A Smith; M.M. Thompson; Frank Van Bockxmeer; M. Waltham; S.E. Matthíasson; G. Thorleifsson; U. Thorsteinsdóttir; J.D. Blankensteijn; J.A.W. Teijink; C. Wijmenga; J. De Graaf; L.A. Kiemeney; J.B. Wild; S.J. Edkins; R.G. Gwilliam; S.E. Hunt; S.C. Potter; J.S. Lindholt; J. Golledge; Paul Norman; A.M. Van Rij; J.T. Powell; P. Eriksson; K. Stefánsson; J.R. Thompson; S.E. Humphries; R.D. Sayers; P. Deloukas; N.J. Samani; M.J. Bown

doi:10.1161/CIRCGENETICS.113.000165

A variant in LDLR is associated with abdominal aortic aneurysm

D.T. Bradley, A.E. Hughes, S.A. Badger, G.T. Jones, S.C. Harrison, B.J. Wright, S.J. Bumpstead, A.F. Baas, S. Grétarsdóttir, K.G. Burnand, A.H. Child, R.E. Clough, G.W. Cockerill, H.M. Hafez, D.J.A. Scott, R.A.S. Ariëns, A.B. Johnson, S. Sohrabi, A Smith, M.M. ThompsonFrank Van Bockxmeer, M. Waltham, S.E. Matthíasson, G. Thorleifsson, U. Thorsteinsdóttir, J.D. Blankensteijn, J.A.W. Teijink, C. Wijmenga, J. De Graaf, L.A. Kiemeney, J.B. Wild, S.J. Edkins, R.G. Gwilliam, S.E. Hunt, S.C. Potter, J.S. Lindholt, J. Golledge, Paul Norman, A.M. Van Rij, J.T. Powell, P. Eriksson, K. Stefánsson, J.R. Thompson, S.E. Humphries, R.D. Sayers, P. Deloukas, N.J. Samani, M.J. Bown

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Abstract

Background-Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance. Methods and Results-A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter =30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P

Original language	English
Pages (from-to)	498-504
Journal	Circulation-Cardiovascular Genetics
Volume	6
Issue number	5
DOIs	https://doi.org/10.1161/CIRCGENETICS.113.000165
Publication status	Published - 2013

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Bradley, D. T., Hughes, A. E., Badger, S. A., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S. J., Baas, A. F., Grétarsdóttir, S., Burnand, K. G., Child, A. H., Clough, R. E., Cockerill, G. W., Hafez, H. M., Scott, D. J. A., Ariëns, R. A. S., Johnson, A. B., Sohrabi, S., Smith, A., ... Bown, M. J. (2013). A variant in LDLR is associated with abdominal aortic aneurysm. Circulation-Cardiovascular Genetics, 6(5), 498-504. https://doi.org/10.1161/CIRCGENETICS.113.000165

@article{195290fa76bb44e49b06012e9f67a824,

title = "A variant in LDLR is associated with abdominal aortic aneurysm",

abstract = "Background-Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance. Methods and Results-A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter =30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P",

author = "D.T. Bradley and A.E. Hughes and S.A. Badger and G.T. Jones and S.C. Harrison and B.J. Wright and S.J. Bumpstead and A.F. Baas and S. Gr{\'e}tarsd{\'o}ttir and K.G. Burnand and A.H. Child and R.E. Clough and G.W. Cockerill and H.M. Hafez and D.J.A. Scott and R.A.S. Ari{\"e}ns and A.B. Johnson and S. Sohrabi and A Smith and M.M. Thompson and \{Van Bockxmeer\}, Frank and M. Waltham and S.E. Matth{\'i}asson and G. Thorleifsson and U. Thorsteinsd{\'o}ttir and J.D. Blankensteijn and J.A.W. Teijink and C. Wijmenga and \{De Graaf\}, J. and L.A. Kiemeney and J.B. Wild and S.J. Edkins and R.G. Gwilliam and S.E. Hunt and S.C. Potter and J.S. Lindholt and J. Golledge and Paul Norman and \{Van Rij\}, A.M. and J.T. Powell and P. Eriksson and K. Stef{\'a}nsson and J.R. Thompson and S.E. Humphries and R.D. Sayers and P. Deloukas and N.J. Samani and M.J. Bown",

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doi = "10.1161/CIRCGENETICS.113.000165",

language = "English",

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pages = "498--504",

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Bradley, DT, Hughes, AE, Badger, SA, Jones, GT, Harrison, SC, Wright, BJ, Bumpstead, SJ, Baas, AF, Grétarsdóttir, S, Burnand, KG, Child, AH, Clough, RE, Cockerill, GW, Hafez, HM, Scott, DJA, Ariëns, RAS, Johnson, AB, Sohrabi, S, Smith, A, Thompson, MM, Van Bockxmeer, F, Waltham, M, Matthíasson, SE, Thorleifsson, G, Thorsteinsdóttir, U, Blankensteijn, JD, Teijink, JAW, Wijmenga, C, De Graaf, J, Kiemeney, LA, Wild, JB, Edkins, SJ, Gwilliam, RG, Hunt, SE, Potter, SC, Lindholt, JS, Golledge, J, Norman, P, Van Rij, AM, Powell, JT, Eriksson, P, Stefánsson, K, Thompson, JR, Humphries, SE, Sayers, RD, Deloukas, P, Samani, NJ & Bown, MJ 2013, 'A variant in LDLR is associated with abdominal aortic aneurysm', Circulation-Cardiovascular Genetics, vol. 6, no. 5, pp. 498-504. https://doi.org/10.1161/CIRCGENETICS.113.000165

TY - JOUR

T1 - A variant in LDLR is associated with abdominal aortic aneurysm

AU - Bradley, D.T.

AU - Hughes, A.E.

AU - Badger, S.A.

AU - Jones, G.T.

AU - Harrison, S.C.

AU - Wright, B.J.

AU - Bumpstead, S.J.

AU - Baas, A.F.

AU - Grétarsdóttir, S.

AU - Burnand, K.G.

AU - Child, A.H.

AU - Clough, R.E.

AU - Cockerill, G.W.

AU - Hafez, H.M.

AU - Scott, D.J.A.

AU - Ariëns, R.A.S.

AU - Johnson, A.B.

AU - Sohrabi, S.

AU - Smith, A

AU - Thompson, M.M.

AU - Van Bockxmeer, Frank

AU - Waltham, M.

AU - Matthíasson, S.E.

AU - Thorleifsson, G.

AU - Thorsteinsdóttir, U.

AU - Blankensteijn, J.D.

AU - Teijink, J.A.W.

AU - Wijmenga, C.

AU - De Graaf, J.

AU - Kiemeney, L.A.

AU - Wild, J.B.

AU - Edkins, S.J.

AU - Gwilliam, R.G.

AU - Hunt, S.E.

AU - Potter, S.C.

AU - Lindholt, J.S.

AU - Golledge, J.

AU - Norman, Paul

AU - Van Rij, A.M.

AU - Powell, J.T.

AU - Eriksson, P.

AU - Stefánsson, K.

AU - Thompson, J.R.

AU - Humphries, S.E.

AU - Sayers, R.D.

AU - Deloukas, P.

AU - Samani, N.J.

AU - Bown, M.J.

PY - 2013

Y1 - 2013

N2 - Background-Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance. Methods and Results-A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter =30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P

AB - Background-Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance. Methods and Results-A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter =30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P

UR - https://www.scopus.com/pages/publications/84892385162

U2 - 10.1161/CIRCGENETICS.113.000165

DO - 10.1161/CIRCGENETICS.113.000165

M3 - Article

SN - 1942-325X

VL - 6

SP - 498

EP - 504

JO - Circulation-Cardiovascular Genetics

JF - Circulation-Cardiovascular Genetics

IS - 5

ER -

A variant in LDLR is associated with abdominal aortic aneurysm

Abstract

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