A variant in LDLR is associated with abdominal aortic aneurysm

D.T. Bradley, A.E. Hughes, S.A. Badger, G.T. Jones, S.C. Harrison, B.J. Wright, S.J. Bumpstead, A.F. Baas, S. Grétarsdóttir, K.G. Burnand, A.H. Child, R.E. Clough, G.W. Cockerill, H.M. Hafez, D.J.A. Scott, R.A.S. Ariëns, A.B. Johnson, S. Sohrabi, A Smith, M.M. ThompsonFrank Van Bockxmeer, M. Waltham, S.E. Matthíasson, G. Thorleifsson, U. Thorsteinsdóttir, J.D. Blankensteijn, J.A.W. Teijink, C. Wijmenga, J. De Graaf, L.A. Kiemeney, J.B. Wild, S.J. Edkins, R.G. Gwilliam, S.E. Hunt, S.C. Potter, J.S. Lindholt, J. Golledge, Paul Norman, A.M. Van Rij, J.T. Powell, P. Eriksson, K. Stefánsson, J.R. Thompson, S.E. Humphries, R.D. Sayers, P. Deloukas, N.J. Samani, M.J. Bown

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Abstract

Background-Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance. Methods and Results-A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter =30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P
Original languageEnglish
Pages (from-to)498-504
JournalCirculation-Cardiovascular Genetics
Volume6
Issue number5
DOIs
Publication statusPublished - 2013

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    Bradley, D. T., Hughes, A. E., Badger, S. A., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S. J., Baas, A. F., Grétarsdóttir, S., Burnand, K. G., Child, A. H., Clough, R. E., Cockerill, G. W., Hafez, H. M., Scott, D. J. A., Ariëns, R. A. S., Johnson, A. B., Sohrabi, S., Smith, A., ... Bown, M. J. (2013). A variant in LDLR is associated with abdominal aortic aneurysm. Circulation-Cardiovascular Genetics, 6(5), 498-504. https://doi.org/10.1161/CIRCGENETICS.113.000165