A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations

M.C. Serban, Amirhossein Sahebkar, S. Dragan, G. Stoichescu-Hogea, S. Ursoniu, F. Andrica, M. Banach

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    Abstract

    © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.Background & aims: The impact of Spirulina supplementation on plasma lipid concentrations has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of Spirulina supplementation on plasma lipid concentrations. Methods: We searched PubMed and Scopus (up to July 03, 2015) to identify randomized controlled trials (RCTs) that investigate the effect Spirulina supplementation on plasma lipid concentrations. Meta-analysis and meta-regression were performed using random-effects models. Results: Random-effect meta-analysis of data from 7 RCTs showed a significant effect of supplementation with spirulina in reducing plasma concentrations of total cholesterol (WMD: -46.76 mg/dL, 95% CI: -67.31 to -26.22, p <0.001), LDL-C (WMD: -41.32 mg/dL, 95% CI: -60.62 to -22.03, p <0.001) and triglycerides (WMD: -44.23 mg/dL, 95% CI: -50.22 to -38.24, p <0.001), and elevating those of HDL-C (WMD: 6.06 mg/dL, 95% CI: 2.37-9.76, p = 0.001). The impact of spirulina on plasma concentrations of total cholesterol (slope: -1.32; 95% CI: -8.58 to 5.93; p = 0.720), LDL-C (slope: -1.01; 95% CI: -8.03 to 6.02; p = 0.778), triglycerides (slope: -1.39; 95% CI: -4.26 to 1.48; p = 0.342) and HDL-C (slope: 1.79, 95% CI: -0.48 to 4.05; p = 0.122) was independent of administered dose. Regarding duration of supplementation with Spirulina, significant associations were found with changes in plasma concentrations of total cholesterol (slope: -1.77; 95% CI: -3.48 to -0.07; p = 0.042), LDL-C (slope: -1.73; 95% CI: -3.40 to -0.06; p = 0.042) HDL-C (slope: 0.91; 95% CI: 0.68-1.14; p <0.001) and triglycerides (slope: -1.39; 95% CI: -2.28 to -0.50; p = 0.002). Conclusions: This meta-analysis showed a significant effect of supplementation with Spirulina in reducing plasma concentrations of total cholesterol, LDL-C, triglycerides and elevating those of HDL-C.
    Original languageEnglish
    Pages (from-to)842-851
    JournalClinical Nutrition
    Volume35
    Issue number4
    DOIs
    Publication statusPublished - 2016

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