A system for the directed evolution of tetracyclines

Louis Henri Scott

    Research output: ThesisDoctoral Thesis

    62 Downloads (Pure)

    Abstract

    Therise of antimicrobial resistance is a major threat to global health that requires action across all government sectors and society. Without new methods for antibiotic discovery, people will die from historically easy to treat infections. This work outlines a new genetic engineering approach that harnesses the power of synthetic biology for the directed evolution of antibiotics in the yeast Saccharomyces cerevisiae. The strength of this platform lies in the use of an evolutionary driving force that selects for the biosynthesis of antibiotics that can overcome bacterial resistance. This system presents a significant addition to the antibiotic discovery toolbox.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date7 Oct 2016
    Publication statusUnpublished - 2016

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