A Sweet Connection? Fructose’s Role in Hepatocellular Carcinoma

Brittany Dewdney, Alexandra Roberts, Liang Qiao, Jacob George, Lionel Hebbard

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Hepatocellular carcinoma is one of few cancer types that continues to grow in incidence and mortality worldwide. With the alarming increase in diabetes and obesity rates, the higher rates of hepatocellular carcinoma are a result of underlying non-alcoholic fatty liver disease. Many have attributed disease progression to an excess consumption of fructose sugar. Fructose has known toxic effects on the liver, including increased fatty acid production, increased oxidative stress, and insulin resistance. These effects have been linked to non-alcoholic fatty liver (NAFLD) disease and a progression to non-alcoholic steatohepatitis (NASH). While the literature suggests fructose may enhance liver cancer progression, the precise mechanisms in which fructose induces tumor formation remains largely unclear. In this review, we summarize the current understanding of fructose metabolism in liver disease and liver tumor development. Furthermore, we consider the latest knowledge of cancer cell metabolism and speculate on additional mechanisms of fructose metabolism in hepatocellular carcinoma.
Original languageEnglish
Article number496
Number of pages20
JournalBiomolecules
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2020
Externally publishedYes

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