A Single gene Inactivation with implications to Diabetes and Multiple Organ Dysfunction Syndrome

Research output: Contribution to conferenceAbstract

Abstract

Statement of the Problem: Specific genes that are involved in epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin structure, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. Epigenetic modifications induced by unhealthy diets or environmental xenobiotics involve adipose tissue and liver with immune alterations that determine the survival of cells in various tissues. Methodology & Theoretical Orientation: Genomic analysis identify the defective gene in various chronic diseases as Sirtuin 1 (Sirt 1), a NAD(+)dependent class III histone deacetylase (HDAC) protein (1) that targets transcription factors to adapt gene expression to metabolic activity, insulin resistance and inflammation. Interests in Sirt 1 have increased since it may override the effects of other anti-aging genes (2) such as Klotho, p66Shc (longevity protein) and Fork head box proteins (FOXO1/FOXO3a). Findings: Unhealthy diets inactivate the calorie sensitive gene Sirtuin 1 (Sirt 1) involved in epigenetic processes that promote immune system alterations, mitochondrial apoptosis, non-alcoholic fatty liver disease, diabetes and nitric oxide (NO) modification with relevance to core body temperature (3) involved with appetite regulation, glucose homeostasis and hepatic xenobiotic metabolism (4). The interplay between NO and epigenetics has attracted interest with relevance to autoimmune disease and mitophagy (3) that has become of critical concern to diabetes and the development of multiple organ disease syndrome
Original languageEnglish
Publication statusPublished - 6 Nov 2018
EventEpigenetics 2017 - Frankfurt, Germany
Duration: 6 Nov 20178 Nov 2017

Conference

ConferenceEpigenetics 2017
CountryGermany
CityFrankfurt
Period6/11/178/11/17

Fingerprint

Multiple Organ Failure
Sirtuin 1
Gene Silencing
Epigenomics
Xenobiotics
Genes
Insulin Resistance
Nitric Oxide
Chronic Disease
Histone Code
Mitochondrial Degradation
Histone Deacetylase 1
Genetic Epigenesis
Diet
Appetite Regulation
Liver
DNA Methylation
Cellular Structures
Body Temperature
NAD

Cite this

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title = "A Single gene Inactivation with implications to Diabetes and Multiple Organ Dysfunction Syndrome",
abstract = "Statement of the Problem: Specific genes that are involved in epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin structure, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. Epigenetic modifications induced by unhealthy diets or environmental xenobiotics involve adipose tissue and liver with immune alterations that determine the survival of cells in various tissues. Methodology & Theoretical Orientation: Genomic analysis identify the defective gene in various chronic diseases as Sirtuin 1 (Sirt 1), a NAD(+)dependent class III histone deacetylase (HDAC) protein (1) that targets transcription factors to adapt gene expression to metabolic activity, insulin resistance and inflammation. Interests in Sirt 1 have increased since it may override the effects of other anti-aging genes (2) such as Klotho, p66Shc (longevity protein) and Fork head box proteins (FOXO1/FOXO3a). Findings: Unhealthy diets inactivate the calorie sensitive gene Sirtuin 1 (Sirt 1) involved in epigenetic processes that promote immune system alterations, mitochondrial apoptosis, non-alcoholic fatty liver disease, diabetes and nitric oxide (NO) modification with relevance to core body temperature (3) involved with appetite regulation, glucose homeostasis and hepatic xenobiotic metabolism (4). The interplay between NO and epigenetics has attracted interest with relevance to autoimmune disease and mitophagy (3) that has become of critical concern to diabetes and the development of multiple organ disease syndrome",
author = "Ian Martins",
year = "2018",
month = "11",
day = "6",
language = "English",
note = "Epigenetics 2017 ; Conference date: 06-11-2017 Through 08-11-2017",

}

A Single gene Inactivation with implications to Diabetes and Multiple Organ Dysfunction Syndrome. / Martins, Ian.

2018. Abstract from Epigenetics 2017, Frankfurt, Germany.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - A Single gene Inactivation with implications to Diabetes and Multiple Organ Dysfunction Syndrome

AU - Martins, Ian

PY - 2018/11/6

Y1 - 2018/11/6

N2 - Statement of the Problem: Specific genes that are involved in epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin structure, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. Epigenetic modifications induced by unhealthy diets or environmental xenobiotics involve adipose tissue and liver with immune alterations that determine the survival of cells in various tissues. Methodology & Theoretical Orientation: Genomic analysis identify the defective gene in various chronic diseases as Sirtuin 1 (Sirt 1), a NAD(+)dependent class III histone deacetylase (HDAC) protein (1) that targets transcription factors to adapt gene expression to metabolic activity, insulin resistance and inflammation. Interests in Sirt 1 have increased since it may override the effects of other anti-aging genes (2) such as Klotho, p66Shc (longevity protein) and Fork head box proteins (FOXO1/FOXO3a). Findings: Unhealthy diets inactivate the calorie sensitive gene Sirtuin 1 (Sirt 1) involved in epigenetic processes that promote immune system alterations, mitochondrial apoptosis, non-alcoholic fatty liver disease, diabetes and nitric oxide (NO) modification with relevance to core body temperature (3) involved with appetite regulation, glucose homeostasis and hepatic xenobiotic metabolism (4). The interplay between NO and epigenetics has attracted interest with relevance to autoimmune disease and mitophagy (3) that has become of critical concern to diabetes and the development of multiple organ disease syndrome

AB - Statement of the Problem: Specific genes that are involved in epigenetics are sensitive to nutritional regulation, oxidative stress and the development of insulin resistance that can result from changes in cellular chromatin structure, DNA methylation and histone modifications with relevance to the global chronic disease epidemic. Epigenetic modifications induced by unhealthy diets or environmental xenobiotics involve adipose tissue and liver with immune alterations that determine the survival of cells in various tissues. Methodology & Theoretical Orientation: Genomic analysis identify the defective gene in various chronic diseases as Sirtuin 1 (Sirt 1), a NAD(+)dependent class III histone deacetylase (HDAC) protein (1) that targets transcription factors to adapt gene expression to metabolic activity, insulin resistance and inflammation. Interests in Sirt 1 have increased since it may override the effects of other anti-aging genes (2) such as Klotho, p66Shc (longevity protein) and Fork head box proteins (FOXO1/FOXO3a). Findings: Unhealthy diets inactivate the calorie sensitive gene Sirtuin 1 (Sirt 1) involved in epigenetic processes that promote immune system alterations, mitochondrial apoptosis, non-alcoholic fatty liver disease, diabetes and nitric oxide (NO) modification with relevance to core body temperature (3) involved with appetite regulation, glucose homeostasis and hepatic xenobiotic metabolism (4). The interplay between NO and epigenetics has attracted interest with relevance to autoimmune disease and mitophagy (3) that has become of critical concern to diabetes and the development of multiple organ disease syndrome

M3 - Abstract

ER -