A simple and robust preparation of N-acetylindoxyls: Precursors for indigogenic substrates

© The Royal Society of Chemistry. A generalised, simple and efficient synthesis of N-acetyl-5-bromo-4-chloroindoxyl and related analogues required for the synthesis of indigogenic substrates to probe for biological activities is reported. The method is both synthetically and operationally simple and represents a significant improvement on existing methods.