A Selective Inhibitor Gal-PUGNAc of Human Lysosomal ß-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells

Keith Stubbs, M.S. Macauley, D.J. Vocadlo

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Gal-PUGNAc (see picture), a highly selective inhibitor for β-hexosaminidases HEXA and HEXB is cell-permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels. Gal-PUGNAc should allow the role of these enzymes to be studied at the cellular level without generating a complex chemical phenotype from concomitant inhibition of O-GlcNAcase.
Original languageEnglish
Pages (from-to)1300-1303
JournalAngewandte Chemie (International Edition)
Volume48
Issue number7
DOIs
Publication statusPublished - 2009

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