TY - JOUR
T1 - A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds
AU - Mooranian, Armin
AU - Zamani, Nassim
AU - Mikov, Momir
AU - Golocorbin-Kon, Svetlana
AU - Stojanovic, Goran
AU - Arfuso, Frank
AU - Kovacevic, Bozica
AU - Al-Salami, Hani
PY - 2020/2
Y1 - 2020/2
N2 - Bile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have β-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and anti-inflammatory drugs, such as probucol (PB). Thus, this study aimed to design and test microcapsules containing a PUBA incorporated with PB and an alginate-Eudragit matrix. Six types of microcapsules were developed without (control) or with (test) PUBA, and tested for internal and external features and β-cell protective effects. The incorporation of PB-alginate-Eudragit with PUBA produced stable microcapsules but did not exert consistent positive effects on cell viability in the hyperglycaemic state, which suggests that PUBA in alginate-Eudragit matrices did not exhibit synergistic effects with PB nor exerted antidiabetic effects.
AB - Bile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have β-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and anti-inflammatory drugs, such as probucol (PB). Thus, this study aimed to design and test microcapsules containing a PUBA incorporated with PB and an alginate-Eudragit matrix. Six types of microcapsules were developed without (control) or with (test) PUBA, and tested for internal and external features and β-cell protective effects. The incorporation of PB-alginate-Eudragit with PUBA produced stable microcapsules but did not exert consistent positive effects on cell viability in the hyperglycaemic state, which suggests that PUBA in alginate-Eudragit matrices did not exhibit synergistic effects with PB nor exerted antidiabetic effects.
UR - http://www.scopus.com/inward/record.url?scp=85077146453&partnerID=8YFLogxK
U2 - 10.1016/j.jsps.2019.11.017
DO - 10.1016/j.jsps.2019.11.017
M3 - Article
SN - 1319-0164
VL - 28
SP - 165
EP - 171
JO - Saudi Pharmaceutical Journal
JF - Saudi Pharmaceutical Journal
IS - 2
ER -