A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds

Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Golocorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic, Hani Al-Salami

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Bile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have β-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and anti-inflammatory drugs, such as probucol (PB). Thus, this study aimed to design and test microcapsules containing a PUBA incorporated with PB and an alginate-Eudragit matrix. Six types of microcapsules were developed without (control) or with (test) PUBA, and tested for internal and external features and β-cell protective effects. The incorporation of PB-alginate-Eudragit with PUBA produced stable microcapsules but did not exert consistent positive effects on cell viability in the hyperglycaemic state, which suggests that PUBA in alginate-Eudragit matrices did not exhibit synergistic effects with PB nor exerted antidiabetic effects.
Original languageEnglish
Pages (from-to)165-171
Number of pages7
JournalSaudi Pharmaceutical Journal
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2020
Externally publishedYes

Cite this