A scoping review protocol on in vivo human plastic exposure and health impacts

Louise M. Goodes, Enoch V.S. Wong, Jennifer Alex, Louise Mofflin, Priyanka Toshniwal, Manuel Brunner, Terena Solomons, Emily White, Omrik Choudhury, Bhedita J. Seewoo, Yannick R. Mulders, Tristan Dale, Hamish J. Newman, Alina Naveed, Andrew B. Lowe, Delia V. Hendrie, Christos Symeonides, Sarah A. Dunlop

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Background: Global plastic production has increased exponentially since the 1960s, with more than 6300 million metric tons of plastic waste generated to date. Studies have found a range of human health outcomes associated with exposure to plastic chemicals. However, only a fraction of plastic chemicals used have been studied in vivo, and then often in animals, for acute toxicological effects. With many questions still unanswered about how long-term exposure to plastic impacts human health, there is an urgent need to map human in vivo research conducted to date, casting a broad net by searching terms for a comprehensive suite of plastic chemical exposures and the widest range of health domains. Methods: This protocol describes a scoping review that will follow the recommended framework outlined in the 2017 Guidance for the Conduct of Joanna Briggs Institute (JBI) Scoping Reviews, to be reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist. A literature search of primary clinical studies in English from 1960 onwards will be conducted in MEDLINE (Ovid) and EMBASE (Ovid) databases. References eligible for inclusion will be identified through a quality-controlled, multi-level screening process. Extracted data will be presented in diagrammatic and tabular form, with a narrative summary addressing the review questions. Discussion: This scoping review will comprehensively map the primary research undertaken to date on plastic exposure and human health. Secondary outputs will include extensive databases on plastic chemicals and human health outcomes/impacts. Systematic review registration: Open Science Framework (OSF)-Standard Pre-Data Collection Registration, https://archive.org/details/osf-registrations-gbxps-v1, https://doi.org/10.17605/OSF.IO/GBXPS.

Original languageEnglish
Article number137
JournalSystematic Reviews
Issue number1
Publication statusPublished - Dec 2022


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