A role for Peroxisome Proliferator-Activated Receptor Beta in T cell development

Isabelle Mothe-Satney, Joseph Murdaca, Brigitte Sibille, Anne Sophie Rousseau, Raphaëlle Squillace, Gwenaëlle Le Menn, Akila Rekima, Frederic Larbret, Juline Pelé, Valérie Verhasselt, Paul A. Grimaldi, Jaap G. Neels

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Metabolism plays an important role in T cell biology and changes in metabolism drive T cell differentiation and fate. Most research on the role of metabolism in T lymphocytes focuses on mature T cells while only few studies have investigated the role of metabolism in T cell development. In this study, we report that activation or overexpression of the transcription factor Peroxisome Proliferator-Activated Receptor β (PPARβ) increases fatty acid oxidation in T cells. Furthermore, using both in vivo and in vitro models, we demonstrate that PPARβ activation/overexpression inhibits thymic T cell development by decreasing proliferation of CD4 CD8 double-negative stage 4 (DN4) thymocytes. These results support a model where PPARβ activation/overexpression favours fatty acid- instead of glucose-oxidation in developing T cells, thereby hampering the proliferative burst normally occurring at the DN4 stage of T cell development. As a consequence, the αβ T cells that are derived from DN4 thymocytes are dramatically decreased in peripheral lymphoid tissues, while the 3 T cell population remains untouched. This is the first report of a direct role for a member of the PPAR family of nuclear receptors in the development of T cells.

Original languageEnglish
Article number34317
Number of pages12
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 29 Sep 2016
Externally publishedYes

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Peroxisome Proliferator-Activated Receptors
T-Lymphocytes
Thymocytes
Fatty Acids
Lymphoid Tissue
Cytoplasmic and Nuclear Receptors
Cell Biology
Cell Differentiation
Transcription Factors

Cite this

Mothe-Satney, I., Murdaca, J., Sibille, B., Rousseau, A. S., Squillace, R., Le Menn, G., ... Neels, J. G. (2016). A role for Peroxisome Proliferator-Activated Receptor Beta in T cell development. Scientific Reports, 6, [34317]. https://doi.org/10.1038/srep34317
Mothe-Satney, Isabelle ; Murdaca, Joseph ; Sibille, Brigitte ; Rousseau, Anne Sophie ; Squillace, Raphaëlle ; Le Menn, Gwenaëlle ; Rekima, Akila ; Larbret, Frederic ; Pelé, Juline ; Verhasselt, Valérie ; Grimaldi, Paul A. ; Neels, Jaap G. / A role for Peroxisome Proliferator-Activated Receptor Beta in T cell development. In: Scientific Reports. 2016 ; Vol. 6.
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Mothe-Satney, I, Murdaca, J, Sibille, B, Rousseau, AS, Squillace, R, Le Menn, G, Rekima, A, Larbret, F, Pelé, J, Verhasselt, V, Grimaldi, PA & Neels, JG 2016, 'A role for Peroxisome Proliferator-Activated Receptor Beta in T cell development' Scientific Reports, vol. 6, 34317. https://doi.org/10.1038/srep34317

A role for Peroxisome Proliferator-Activated Receptor Beta in T cell development. / Mothe-Satney, Isabelle; Murdaca, Joseph; Sibille, Brigitte; Rousseau, Anne Sophie; Squillace, Raphaëlle; Le Menn, Gwenaëlle; Rekima, Akila; Larbret, Frederic; Pelé, Juline; Verhasselt, Valérie; Grimaldi, Paul A.; Neels, Jaap G.

In: Scientific Reports, Vol. 6, 34317, 29.09.2016.

Research output: Contribution to journalArticle

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AU - Mothe-Satney, Isabelle

AU - Murdaca, Joseph

AU - Sibille, Brigitte

AU - Rousseau, Anne Sophie

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AU - Le Menn, Gwenaëlle

AU - Rekima, Akila

AU - Larbret, Frederic

AU - Pelé, Juline

AU - Verhasselt, Valérie

AU - Grimaldi, Paul A.

AU - Neels, Jaap G.

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Mothe-Satney I, Murdaca J, Sibille B, Rousseau AS, Squillace R, Le Menn G et al. A role for Peroxisome Proliferator-Activated Receptor Beta in T cell development. Scientific Reports. 2016 Sep 29;6. 34317. https://doi.org/10.1038/srep34317