A review of the importance of immune responses in luminal B breast cancer

Delia J. Nelson, Briony Clark, Kylie Munyard, Vincent Williams, David Groth, Jespal Gill, Henry Preston, Arlene Chan

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies.

Original languageEnglish
Article numbere1282590
Number of pages10
JournalOncoImmunology
Volume6
Issue number3
DOIs
Publication statusPublished - 19 Jan 2017
Externally publishedYes

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Immunosuppressive Agents
Breast Neoplasms
Immune System
Lymph Nodes
Therapeutics
Neoplasms

Cite this

Nelson, Delia J. ; Clark, Briony ; Munyard, Kylie ; Williams, Vincent ; Groth, David ; Gill, Jespal ; Preston, Henry ; Chan, Arlene. / A review of the importance of immune responses in luminal B breast cancer. In: OncoImmunology. 2017 ; Vol. 6, No. 3.
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A review of the importance of immune responses in luminal B breast cancer. / Nelson, Delia J.; Clark, Briony; Munyard, Kylie; Williams, Vincent; Groth, David; Gill, Jespal; Preston, Henry; Chan, Arlene.

In: OncoImmunology, Vol. 6, No. 3, e1282590, 19.01.2017.

Research output: Contribution to journalReview article

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T1 - A review of the importance of immune responses in luminal B breast cancer

AU - Nelson, Delia J.

AU - Clark, Briony

AU - Munyard, Kylie

AU - Williams, Vincent

AU - Groth, David

AU - Gill, Jespal

AU - Preston, Henry

AU - Chan, Arlene

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