A review of the importance of immune responses in luminal B breast cancer

Delia J. Nelson, Briony Clark, Kylie Munyard, Vincent Williams, David Groth, Jespal Gill, Henry Preston, Arlene Chan

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies.

Original languageEnglish
Article numbere1282590
Number of pages10
JournalOncoImmunology
Volume6
Issue number3
DOIs
Publication statusPublished - 19 Jan 2017
Externally publishedYes

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