Abstract
Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies.
| Original language | English |
|---|---|
| Article number | e1282590 |
| Number of pages | 10 |
| Journal | OncoImmunology |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 19 Jan 2017 |
| Externally published | Yes |
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A review of the importance of immune responses in luminal B breast cancer. / Nelson, Delia J.; Clark, Briony; Munyard, Kylie; Williams, Vincent; Groth, David; Gill, Jespal; Preston, Henry; Chan, Arlene.
In: OncoImmunology, Vol. 6, No. 3, e1282590, 19.01.2017.Research output: Contribution to journal › Review article
TY - JOUR
T1 - A review of the importance of immune responses in luminal B breast cancer
AU - Nelson, Delia J.
AU - Clark, Briony
AU - Munyard, Kylie
AU - Williams, Vincent
AU - Groth, David
AU - Gill, Jespal
AU - Preston, Henry
AU - Chan, Arlene
PY - 2017/1/19
Y1 - 2017/1/19
N2 - Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies.
AB - Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies.
KW - Anticancer immunity
KW - checkpoint molecules
KW - luminal B breast cancer
KW - predictive
KW - prognostic
UR - http://www.scopus.com/inward/record.url?scp=85014428993&partnerID=8YFLogxK
U2 - 10.1080/2162402X.2017.1282590
DO - 10.1080/2162402X.2017.1282590
M3 - Review article
VL - 6
JO - Oncolmmunology
JF - Oncolmmunology
SN - 2162-4011
IS - 3
M1 - e1282590
ER -