A review of optical coherence elastography: Fundamentals, techniques and prospects

Brendan Kennedy, Kelsey Kennedy, David Sampson

    Research output: Contribution to journalReview article

    174 Citations (Scopus)

    Abstract

    In optical coherence elastography, images are formed by mapping a mechanical property of tissue. Such images, known as elastograms, are formed on the microscale, intermediate between that of cells and whole organs. Optical coherence elastography holds great promise for detecting and monitoring the altered mechanical properties that accompany many clinical conditions and pathologies, particularly in cancer, cardiovascular disease and eye disease. In this review, we first consider how the mechanical properties of tissue are linked with tissue function and pathology. We then describe currently prominent optical coherence elastography techniques, with emphasis on the methods of mechanical loading and displacement estimation. We highlight the sensitivity to microstrain deformations at tens of micrometer resolution. Throughout, optical coherence elastography is considered in the context of other elastography methods, mainly ultrasound elastography and magnetic resonance elastography. This context serves to highlight its advantages, early stage of development of applications, and strong prospects for future impact. © 1995-2012 IEEE.
    Original languageEnglish
    Pages (from-to)1-17
    JournalIEEE Journal of Selected Topics in Quantum Electronics
    Volume20
    Issue number2
    DOIs
    Publication statusPublished - 2014

    Fingerprint Dive into the research topics of 'A review of optical coherence elastography: Fundamentals, techniques and prospects'. Together they form a unique fingerprint.

    Cite this