A Review of Gene, Drug and Cell-Based Therapies for Usher Syndrome

Lucy S. French; Carla B. Mellough; Fred K. Chen; Livia S. Carvalho

doi:10.3389/fncel.2020.00183

A Review of Gene, Drug and Cell-Based Therapies for Usher Syndrome

Lucy S. French, Carla B. Mellough, Fred K. Chen, Livia S. Carvalho

Research output: Contribution to journal › Review article

Abstract

Usher syndrome is a genetic disorder causing neurosensory hearing loss and blindness from retinitis pigmentosa (RP). Adaptive techniques such as braille, digital and optical magnifiers, mobility training, cochlear implants, or other assistive listening devices are indispensable for reducing disability. However, there is currently no treatment to reduce or arrest sensory cell degeneration. There are several classes of treatments for Usher syndrome being investigated. The present article reviews the progress this research has made towards delivering commercial options for patients with Usher syndrome.

Original language	English
Article number	183
Journal	Frontiers in Cellular Neuroscience
Volume	14
DOIs	https://doi.org/10.3389/fncel.2020.00183
Publication status	Published - 9 Jul 2020

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10.3389/fncel.2020.00183Licence: CC BY

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Projects

2 Active

Accelerating the identification and treatment of splice-altering mutations underlying inherited retinal diseases

Chen, F., McLenachan, S., Fletcher, S. & Cunningham, P.

National Health & Medical Research Council NHMRC

1/01/20 → 31/12/24

Project: Research

MRFF - Developing Personalised Treatment for Retinal Degeneration

Chen, F.

National Health & Medical Research Council NHMRC

1/01/18 → 31/12/21

Project: Research

Cite this

French, L. S., Mellough, C. B., Chen, F. K., & Carvalho, L. S. (2020). A Review of Gene, Drug and Cell-Based Therapies for Usher Syndrome. Frontiers in Cellular Neuroscience, 14, [183]. https://doi.org/10.3389/fncel.2020.00183

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