A Region Centromeric of the Major Histocompatibility Complex Class I Region Is as Highly Polymorphic as HLA-B: Implications for Recombination

Lawrence Abraham, G. Grimsley, C. Leelayuwat, D.C. Townend, M. Pinelli, Frank Christiansen, R.L. Dawkins

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    12 Citations (Scopus)

    Abstract

    Two hallmarks of the MHC are the high degree of polymorphism apparent at multiple loci and ''linkage disequilibrium.'' The data presented here suggest that a consequence of selection at a particular locus may be the inhibition of recombination through the accumulation of DNA sequence polymorphisms. Equivalent 6.4 kb regions from a locus, CL1, located approximately 25-30 kb centromeric of HLA-B, were sequenced for three ancestral haplotypes: A1,B8,DR3; A30,B18,DR3; and A1,B57,DR7. Comparison of the sequences indicated that the level of DNA sequence polymorphism was high when compared with the TNF region; approximately 80 single nucleotide differences were found when comparing any two sequences. In addition, multiple deletions/insertions were present. We believe that the degree of poly morphism within the CL interval may be adequate to at least partially inhibit recombination between the haplotypes studied.
    Original languageEnglish
    Pages (from-to)75-82
    JournalHuman Immunology
    Volume38
    DOIs
    Publication statusPublished - 1993

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