Projects per year
Abstract
Background and objective
The high incidence of cardiovascular disease (CVD) in chronic kidney disease (CKD) is related partially to chronic inflammation. n-3 Fatty acids have been shown to have anti-inflammatory effects and to reduce the risk of CVD. Specialized Proresolving Lipid Mediators (SPMs) derived from the n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) actively promote the resolution of inflammation. This study evaluates the effects of n-3 fatty acid supplementation on plasma SPMs in patients with CKD.
Methods
In a double-blind, placebo-controlled intervention of factorial design, 85 patients were randomized to either n-3 fatty acids (4 g), Coenzyme Q10 (CoQ) (200 mg), both supplements, or control (4 g olive oil), daily for 8 weeks. The SPMs 18-HEPE, 17-HDHA, RvD1, 17R-RvD1, and RvD2, were measured in plasma by liquid chromatography–tandem mass spectrometry before and after intervention.
Results
Seventy four patients completed the 8 weeks intervention. n-3 Fatty acids but not CoQ significantly increased (P < 0.0001) plasma levels of 18-HEPE and 17-HDHA, the upstream precursors to the E- and D-series resolvins, respectively. RvD1 was significantly increased (P = 0.036) after n-3 fatty acids, but no change was seen in other SPMs. In regression analysis the increase in 18-HEPE and 17-HDHA after n-3 fatty acids was significantly predicted by the change in platelet EPA and DHA, respectively.
Conclusion
SPMs are increased after 8 weeks n-3 fatty acid supplementation in patients with CKD. This may have important implications for limiting ongoing low grade inflammation in CKD.
Original language | English |
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Pages (from-to) | 331-336 |
Number of pages | 6 |
Journal | Clinical Nutrition |
Volume | 35 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Apr 2016 |
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Dive into the research topics of 'A randomized controlled trial of the effects of n-3 fatty acids on resolvins in chronic kidney disease.'. Together they form a unique fingerprint.Projects
- 3 Finished
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NHMRC Research Fellowships - Trevor Mori
National Health & Medical Research Council NHMRC
1/01/13 → 31/12/17
Project: Research
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The Effects of Fish Oil Supplements & Novel Anti-Inflammatory Metabolites & Telomere Length in Early & Later Life - Potential Implications for Long Term Cardiovascular Risk
Mori, T., Huang, R., Prescott, S., Beilin, L., Fenech, M. & O'Callaghan, N.
National Health & Medical Research Council NHMRC
1/01/11 → 31/12/14
Project: Research
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Effects of Omega-3 fatty Acids and Coenzyme Q10 on Cardiovascular Risk in Chronic Renal Failure
Mori, T., Watts, G., Puddey, I., Irish, A. & Beilin, L.
1/01/04 → 31/12/06
Project: Research