A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)

Michelle K. Lupton, Gail A. Robinson, Robert J. Adam, Stephen Rose, Gerard J. Byrne, Olivier Salvado, Nancy A. Pachana, Osvaldo P. Almeida, Kerrie McAloney, Scott D. Gordon, Parnesh Raniga, Amir Fazlollahi, Ying Xia, Amelia Ceslis, Saurabh Sonkusare, Qing Zhang, Mahnoosh Kholghi, Mohan Karunanithi, Philip E. Mosley, Jinglei LvLéonie Borne, Jessica Adsett, Natalie Garden, Jurgen Fripp, Nicholas G. Martin, Christine C. Guo, Michael Breakspear

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling over 3800 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for detailed functional, structural and molecular neuroimaging, lifestyle monitoring, detailed neurocognitive testing, plus blood sample donation. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics.

Original languageEnglish
Article number102527
JournalNeuroImage: Clinical
Volume29
DOIs
Publication statusPublished - Jan 2021

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