A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)

Michelle K. Lupton; Gail A. Robinson; Robert J. Adam; Stephen Rose; Gerard J. Byrne; Olivier Salvado; Nancy A. Pachana; Osvaldo P. Almeida; Kerrie McAloney; Scott D. Gordon; Parnesh Raniga; Amir Fazlollahi; Ying Xia; Amelia Ceslis; Saurabh Sonkusare; Qing Zhang; Mahnoosh Kholghi; Mohan Karunanithi; Philip E. Mosley; Jinglei Lv; Léonie Borne; Jessica Adsett; Natalie Garden; Jurgen Fripp; Nicholas G. Martin; Christine C. Guo; Michael Breakspear

doi:10.1016/j.nicl.2020.102527

A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)

Michelle K. Lupton, Gail A. Robinson, Robert J. Adam, Stephen Rose, Gerard J. Byrne, Olivier Salvado, Nancy A. Pachana, Osvaldo P. Almeida, Kerrie McAloney, Scott D. Gordon, Parnesh Raniga, Amir Fazlollahi, Ying Xia, Amelia Ceslis, Saurabh Sonkusare, Qing Zhang, Mahnoosh Kholghi, Mohan Karunanithi, Philip E. Mosley, Jinglei LvLéonie Borne, Jessica Adsett, Natalie Garden, Jurgen Fripp, Nicholas G. Martin, Christine C. Guo, Michael Breakspear

Psychiatry

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling over 3800 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for detailed functional, structural and molecular neuroimaging, lifestyle monitoring, detailed neurocognitive testing, plus blood sample donation. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics.

Original language	English
Article number	102527
Journal	NeuroImage: Clinical
Volume	29
DOIs	https://doi.org/10.1016/j.nicl.2020.102527
Publication status	Published - Jan 2021

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Lupton, M. K., Robinson, G. A., Adam, R. J., Rose, S., Byrne, G. J., Salvado, O., Pachana, N. A., Almeida, O. P., McAloney, K., Gordon, S. D., Raniga, P., Fazlollahi, A., Xia, Y., Ceslis, A., Sonkusare, S., Zhang, Q., Kholghi, M., Karunanithi, M., Mosley, P. E., ... Breakspear, M. (2021). A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA). NeuroImage: Clinical, 29, Article 102527. https://doi.org/10.1016/j.nicl.2020.102527

@article{52ce0d540c084a45872af87cfc8e48e2,

title = "A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)",

abstract = "This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling over 3800 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for detailed functional, structural and molecular neuroimaging, lifestyle monitoring, detailed neurocognitive testing, plus blood sample donation. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics.",

keywords = "Alzheimer's disease, At risk cohort, Genetic risk prediction, Neuroimaging, Neuropsychology, Protocol",

author = "Lupton, {Michelle K.} and Robinson, {Gail A.} and Adam, {Robert J.} and Stephen Rose and Byrne, {Gerard J.} and Olivier Salvado and Pachana, {Nancy A.} and Almeida, {Osvaldo P.} and Kerrie McAloney and Gordon, {Scott D.} and Parnesh Raniga and Amir Fazlollahi and Ying Xia and Amelia Ceslis and Saurabh Sonkusare and Qing Zhang and Mahnoosh Kholghi and Mohan Karunanithi and Mosley, {Philip E.} and Jinglei Lv and L{\'e}onie Borne and Jessica Adsett and Natalie Garden and Jurgen Fripp and Martin, {Nicholas G.} and Guo, {Christine C.} and Michael Breakspear",

year = "2021",

month = jan,

doi = "10.1016/j.nicl.2020.102527",

language = "English",

volume = "29",

journal = "NeuroImage: Clinical",

issn = "2213-1582",

publisher = "Elsevier",

}

Lupton, MK, Robinson, GA, Adam, RJ, Rose, S, Byrne, GJ, Salvado, O, Pachana, NA, Almeida, OP, McAloney, K, Gordon, SD, Raniga, P, Fazlollahi, A, Xia, Y, Ceslis, A, Sonkusare, S, Zhang, Q, Kholghi, M, Karunanithi, M, Mosley, PE, Lv, J, Borne, L, Adsett, J, Garden, N, Fripp, J, Martin, NG, Guo, CC & Breakspear, M 2021, 'A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)', NeuroImage: Clinical, vol. 29, 102527. https://doi.org/10.1016/j.nicl.2020.102527

TY - JOUR

T1 - A prospective cohort study of prodromal Alzheimer's disease

T2 - Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)

AU - Lupton, Michelle K.

AU - Robinson, Gail A.

AU - Adam, Robert J.

AU - Rose, Stephen

AU - Byrne, Gerard J.

AU - Salvado, Olivier

AU - Pachana, Nancy A.

AU - Almeida, Osvaldo P.

AU - McAloney, Kerrie

AU - Gordon, Scott D.

AU - Raniga, Parnesh

AU - Fazlollahi, Amir

AU - Xia, Ying

AU - Ceslis, Amelia

AU - Sonkusare, Saurabh

AU - Zhang, Qing

AU - Kholghi, Mahnoosh

AU - Karunanithi, Mohan

AU - Mosley, Philip E.

AU - Lv, Jinglei

AU - Borne, Léonie

AU - Adsett, Jessica

AU - Garden, Natalie

AU - Fripp, Jurgen

AU - Martin, Nicholas G.

AU - Guo, Christine C.

AU - Breakspear, Michael

PY - 2021/1

Y1 - 2021/1

N2 - This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling over 3800 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for detailed functional, structural and molecular neuroimaging, lifestyle monitoring, detailed neurocognitive testing, plus blood sample donation. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics.

AB - This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling over 3800 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for detailed functional, structural and molecular neuroimaging, lifestyle monitoring, detailed neurocognitive testing, plus blood sample donation. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics.

KW - Alzheimer's disease

KW - At risk cohort

KW - Genetic risk prediction

KW - Neuroimaging

KW - Neuropsychology

KW - Protocol

UR - http://www.scopus.com/inward/record.url?scp=85099322425&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2020.102527

DO - 10.1016/j.nicl.2020.102527

M3 - Article

C2 - 33341723

AN - SCOPUS:85099322425

SN - 2213-1582

VL - 29

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

M1 - 102527

ER -

A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)

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