A prospective analysis of micronutrient status in quiescent in flammatory bowel disease

Morag Jane MacMaster; Spyridoula Damianopoulou; Christina Thomson; Dinesh Talwar; Fiona Stefanowicz; Anthony Catchpole; Konstantinos Gerasimidis; Daniel R. Gaya

doi:10.1016/j.clnu.2020.05.010

A prospective analysis of micronutrient status in quiescent in flammatory bowel disease

Morag Jane MacMaster, Spyridoula Damianopoulou, Christina Thomson, Dinesh Talwar, Fiona Stefanowicz, Anthony Catchpole, Konstantinos Gerasimidis, Daniel R. Gaya

Research output: Contribution to journal › Article › peer-review

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Abstract

Background and aims: ESPEN guidelines advocate patients with inflammatory bowel disease (IBD) have their micronutrient levels checked regularly. This study described the micronutrient status of patients with quiescent IBD and explores whether biochemical micronutrient deficiencies related to time to subsequent disease relapse.

Methods: Sixteen micronutrients were measured prospectively in blood of patients with IBD in clinical remission [Harvey Bradshaw Index (HBI)

Results: Ninety-three patients were enrolled; Fifty (54%) were also in biochemical remission defined as a normal faecal calprotectin (

Conclusion: We identified biochemical deficiencies for several micronutrients among adults with IBD clinically in remission. We have also highlighted a significant association between zinc deficiency and time to subsequent disease relapse in patients with CD which needs further investigation. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Original language	English
Pages (from-to)	327-331
Number of pages	5
Journal	Clinical Nutrition
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/j.clnu.2020.05.010
Publication status	Published - Jan 2021
Externally published	Yes

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title = "A prospective analysis of micronutrient status in quiescent in flammatory bowel disease",

abstract = "Background and aims: ESPEN guidelines advocate patients with inflammatory bowel disease (IBD) have their micronutrient levels checked regularly. This study described the micronutrient status of patients with quiescent IBD and explores whether biochemical micronutrient deficiencies related to time to subsequent disease relapse.Methods: Sixteen micronutrients were measured prospectively in blood of patients with IBD in clinical remission [Harvey Bradshaw Index (HBI)Results: Ninety-three patients were enrolled; Fifty (54%) were also in biochemical remission defined as a normal faecal calprotectin (Conclusion: We identified biochemical deficiencies for several micronutrients among adults with IBD clinically in remission. We have also highlighted a significant association between zinc deficiency and time to subsequent disease relapse in patients with CD which needs further investigation. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.",

keywords = "Micronutrients, Vitamins, Minerals, Trace elements, Inflammatory bowel disease, Nutrition, NUTRITION, CHILDREN, VITAMIN, IMPACT",

author = "MacMaster, {Morag Jane} and Spyridoula Damianopoulou and Christina Thomson and Dinesh Talwar and Fiona Stefanowicz and Anthony Catchpole and Konstantinos Gerasimidis and Gaya, {Daniel R.}",

year = "2021",

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doi = "10.1016/j.clnu.2020.05.010",

language = "English",

volume = "40",

pages = "327--331",

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T1 - A prospective analysis of micronutrient status in quiescent in flammatory bowel disease

AU - MacMaster, Morag Jane

AU - Damianopoulou, Spyridoula

AU - Thomson, Christina

AU - Talwar, Dinesh

AU - Stefanowicz, Fiona

AU - Catchpole, Anthony

AU - Gerasimidis, Konstantinos

AU - Gaya, Daniel R.

PY - 2021/1

Y1 - 2021/1

N2 - Background and aims: ESPEN guidelines advocate patients with inflammatory bowel disease (IBD) have their micronutrient levels checked regularly. This study described the micronutrient status of patients with quiescent IBD and explores whether biochemical micronutrient deficiencies related to time to subsequent disease relapse.Methods: Sixteen micronutrients were measured prospectively in blood of patients with IBD in clinical remission [Harvey Bradshaw Index (HBI)Results: Ninety-three patients were enrolled; Fifty (54%) were also in biochemical remission defined as a normal faecal calprotectin (Conclusion: We identified biochemical deficiencies for several micronutrients among adults with IBD clinically in remission. We have also highlighted a significant association between zinc deficiency and time to subsequent disease relapse in patients with CD which needs further investigation. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

AB - Background and aims: ESPEN guidelines advocate patients with inflammatory bowel disease (IBD) have their micronutrient levels checked regularly. This study described the micronutrient status of patients with quiescent IBD and explores whether biochemical micronutrient deficiencies related to time to subsequent disease relapse.Methods: Sixteen micronutrients were measured prospectively in blood of patients with IBD in clinical remission [Harvey Bradshaw Index (HBI)Results: Ninety-three patients were enrolled; Fifty (54%) were also in biochemical remission defined as a normal faecal calprotectin (Conclusion: We identified biochemical deficiencies for several micronutrients among adults with IBD clinically in remission. We have also highlighted a significant association between zinc deficiency and time to subsequent disease relapse in patients with CD which needs further investigation. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

KW - Micronutrients

KW - Vitamins

KW - Minerals

KW - Trace elements

KW - Inflammatory bowel disease

KW - Nutrition

KW - NUTRITION

KW - CHILDREN

KW - VITAMIN

KW - IMPACT

U2 - 10.1016/j.clnu.2020.05.010

DO - 10.1016/j.clnu.2020.05.010

M3 - Article

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SN - 0261-5614

VL - 40

SP - 327

EP - 331

JO - Clinical Nutrition

JF - Clinical Nutrition

IS - 1

ER -

A prospective analysis of micronutrient status in quiescent in flammatory bowel disease

Abstract

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