A prospective analysis of micronutrient status in quiescent in flammatory bowel disease

Morag Jane MacMaster, Spyridoula Damianopoulou, Christina Thomson, Dinesh Talwar, Fiona Stefanowicz, Anthony Catchpole, Konstantinos Gerasimidis, Daniel R. Gaya

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Background and aims: ESPEN guidelines advocate patients with inflammatory bowel disease (IBD) have their micronutrient levels checked regularly. This study described the micronutrient status of patients with quiescent IBD and explores whether biochemical micronutrient deficiencies related to time to subsequent disease relapse.

Methods: Sixteen micronutrients were measured prospectively in blood of patients with IBD in clinical remission [Harvey Bradshaw Index (HBI)

Results: Ninety-three patients were enrolled; Fifty (54%) were also in biochemical remission defined as a normal faecal calprotectin (

Conclusion: We identified biochemical deficiencies for several micronutrients among adults with IBD clinically in remission. We have also highlighted a significant association between zinc deficiency and time to subsequent disease relapse in patients with CD which needs further investigation. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalClinical Nutrition
Issue number1
Publication statusPublished - Jan 2021
Externally publishedYes


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